13945-59-0 Usage
Description
Ethyl [[4-(acetylamino)phenyl]sulphonyl]carbamate is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals, particularly in the production of Carbutamide (C183300), a well-known antidiabetic agent. ethyl [[4-(acetylamino)phenyl]sulphonyl]carbamate plays a significant role in the development of medications that help manage blood sugar levels in patients with diabetes.
Uses
Used in Pharmaceutical Industry:
Ethyl [[4-(acetylamino)phenyl]sulphonyl]carbamate is used as an intermediate in the synthesis of Carbutamide (C183300) for the development of antidiabetic medications. The compound contributes to the creation of drugs that effectively manage blood sugar levels, providing a crucial treatment option for individuals with diabetes.
Used in Antidiabetic Applications:
Ethyl [[4-(acetylamino)phenyl]sulphonyl]carbamate is utilized in the production of Carbutamide, an antidiabetic agent that helps regulate blood sugar levels in patients with diabetes. By being a part of the synthesis process, this compound plays a vital role in the development of medications that can improve the quality of life for individuals living with diabetes and help them maintain proper glucose control.
Check Digit Verification of cas no
The CAS Registry Mumber 13945-59-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,9,4 and 5 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 13945-59:
(7*1)+(6*3)+(5*9)+(4*4)+(3*5)+(2*5)+(1*9)=120
120 % 10 = 0
So 13945-59-0 is a valid CAS Registry Number.
InChI:InChI=1/C11H14N2O5S/c1-3-18-11(15)13-19(16,17)10-6-4-9(5-7-10)12-8(2)14/h4-7H,3H2,1-2H3,(H,12,14)(H,13,15)
13945-59-0Relevant articles and documents
Inhibition of carbonic anhydrase II by sulfonamide derivatives
Xuan,Zhan,Zhang,Li,Zheng
, p. 412 - 415 (2021/11/22)
A series of sulfonamide derivatives were synthesized, and the enzyme inhibitory activity of the synthesized compounds on carbonic anhydrase II was evaluated. Through molecular docking studies, it was found that compounds 1b, 1e, 2a, 2b, 3a have a strong binding affinity to carbonic anhydrase II. The IC50 values of the four compounds 1e, 2b, 3a, and 3b were lower than that of the positive control drug acetazolamide. What’s more, the compounds had a high inhibitory activity for A549 lung cancer cell growth, among them, 1e and 3a could inhibit both carbonic anhydrase II and lung cancer cell proliferation.