1398358-62-7

Basic information

• Product Name: 3-(4-chlorobutanoyl)-1-tosyl-1H-indole-5-carbonitrile
• Synonyms: 3-(4-chlorobutanoyl)-1-tosyl-1H-indole-5-carbonitrile
• CAS NO: 1398358-62-7
• Molecular Weight: 400.886
• Mol File: 1398358-62-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-(4-chlorobutanoyl)-1-tosyl-1H-indole-5-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-chlorobutanoyl)-1-tosyl-1H-indole-5-carbonitrile(1398358-62-7)
• EPA Substance Registry System: 3-(4-chlorobutanoyl)-1-tosyl-1H-indole-5-carbonitrile(1398358-62-7)

Safety Data

• Hazardous Substances Data: 1398358-62-7(Hazardous Substances Data)

Usage

Chemical structure

3-(4-chlorobutanoyl)-1-tosyl-1H-indole-5-carbonitrile

Properties

1. Tosylated indole derivative
2. Chlorobutanoyl substituent at the 3-position
3. Cyano group at the 5-position

Potential applications

1. Organic synthesis
2. Pharmaceutical research
3. Medicinal chemistry

Uses

1. Unique structure
2. Potential biological activities
Further research needed to fully understand properties and potential uses.

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 4635-59-0 4-Chlorobutanoyl chloride 
• 276863-95-7 3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile 
• 15861-24-2 1H-indole-5-carbonitrile 
• 32685-23-7 5-Cyano-1-(p-toluenesulfonyl)indole 

Downstream Products

• 163521-12-8 vilazodone 
• 1398358-69-4 1-p-toluenesulfonyl-3-(4-chlorobutyl)-5-cyanoindole 
• 1415760-77-8 5-[4-[4-[5-cyano-1-(p-toluenesulfonyl)-1H-indol-3-yl]butyl]piperazin-1-yl]benzofuran-2-carboxamide 

Relevant articles and documents

A class of indole derivatives and preparation methods and uses thereof

The present invention relates to the field of medicinal chemistry, discloses a class of indole derivatives and preparation methods and uses thereof. The present invention also discloses a compound comprising the indole structure or a pharmaceutically acce

Phenyl sulfide structure-containing compound or pharmaceutically acceptable salt, preparation method and application thereof

The invention discloses a phenyl sulfide structure-containing compound with a structure as shown in a general formula (I) or pharmaceutically acceptable salt, a preparation method and application thereof. The compound containing the phenyl sulfide structu

Scale-up synthesis of antidepressant drug vilazodone

A scale-up synthesis of antidepressant drug vilazodone was accomplished in five steps. Friedel-Crafts acylation of 1-tosyl-1H-indole-5-carbonitrile with 4-chlorobutyryl chloride, selective deoxygenation in NaBH4/CF 3COOH system coupled with ethyl 5-(piperazin-1-yl)-benzofuran-2- carboxylate hydrochloride, one-step deprotection and esterolysis, and the final ammonolysis led to the target molecule vilazodone in 52.4% overall yield and 99.7% purity. This convenient and economical procedure is remarkably applicable for scale-up production.