1399327-76-4

Basic information

• Product Name: 6-fluoro-2-(4-chlorophenyl)quinazoline
• Synonyms: 6-fluoro-2-(4-chlorophenyl)quinazoline
• CAS NO: 1399327-76-4
• Molecular Weight: 258.682
• Mol File: 1399327-76-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 6-fluoro-2-(4-chlorophenyl)quinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-fluoro-2-(4-chlorophenyl)quinazoline(1399327-76-4)
• EPA Substance Registry System: 6-fluoro-2-(4-chlorophenyl)quinazoline(1399327-76-4)

Safety Data

• Hazardous Substances Data: 1399327-76-4(Hazardous Substances Data)

Upstream product

• 13939-06-5 molybdenum hexacarbonyl 
• 623-03-0 4-Cyanochlorobenzene 
• 771572-99-7 2-(aminomethyl)-4-fluoroaniline 
• 873-76-7 para-Chlorobenzyl alcohol 
• 104-88-1 4-chlorobenzaldehyde 
• 14401-51-5 4-chlorobenzamidine hydrochloride 
• 202865-66-5 2-bromo-5-fluorobenzyl alcohol 
• 747392-34-3 1-(2-bromo-5-fluorophenyl)methanamine 
• 115297-57-9 4-chlorobenzene-1-carboximidamide hydrogeniodide 
• 112399-50-5 2-bromo-5-fluorobenzyl bromide 

Relevant articles and documents

Palladium-catalyzed carbonylative synthesis of quinazolines: Silane act as better nucleophile than amidine

A palladium-catalyzed reductive carbonylation reaction has been developed for the synthesis of quinazolines. With N-(2-iodophenyl)benzimidamide as starting materials, a series of quinazolines were obtained through the aromatic aldehyde intermediates in moderate to good yields with good functional group compatibilities. In this system, silane act as better nucleophile than amidine.

Divergent Synthesis of Quinazolines Using Organocatalytic Domino Strategies under Aerobic Conditions

An easy and efficient organocatalytic approach to the synthesis of 2-substituted quinazolines is described based on the reaction between 2-aminobenzylamines and aldehydes or alcohols or amines. Three organocatalytic platforms were investigated, using 3-nitropyridine, pyridine N-oxide, and vitamin B3. Having established the new catalytic systems, the tandem transformations of 2-aminobenzylamines to give substituted quinazolines were achieved in excellent yields and with a broad substrate scope, with no formation of toxic side-products. The investigated conditions are not restricted to the use of aldehydes; the protocol also works well with alcohols or amines as substrates. These are oxidized in situ to the corresponding aldehydes to achieve the successful transformation. A mechanistic proposal has been drawn up based on control experiments. We found that under aerobic conditions, catalytic amounts of H2O2 can be generated; this plays a key role in the efficacy of the described approach. The green chemistry metrics of the developed method are also presented. The E factor of 8.18 mg/1 mg demonstrates that the reported method is an excellent complement to previous protocols.

Copper-catalyzed domino reaction between 1-(2-halophenyl)methanamines and amidines or imidates for the synthesis of 2-substituted quinazolines

The CuI-catalyzed domino reaction between 1-(2-bromophenyl)methanamines and amidines using K3PO4 as the base, pivalic acid as the additive, and aerial oxygen as the oxidant gives access to substituted quinazolines in a single step wi