1400304-33-7

Basic information

• Product Name: C₂₀H₂₂N₂O₄
• CAS NO: 1400304-33-7
• Molecular Weight: 354.406
• Mol File: 1400304-33-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₂₂N₂O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₂₂N₂O₄(1400304-33-7)
• EPA Substance Registry System: C₂₀H₂₂N₂O₄(1400304-33-7)

Safety Data

• Hazardous Substances Data: 1400304-33-7(Hazardous Substances Data)

Upstream product

• 73325-67-4 4-<(N-benzylamino)methyl>pyridine 
• 1400304-25-7 C₁₇H₁₈N₂O₂ 
• 541-41-3 chloroformic acid ethyl ester 

Relevant articles and documents

Intramolecular cyclization manifolds of 4-Alkylpyridines bearing ambiphilic side chains: Construction of spirodihydropyridines or benzylic cyclization via anhydrobase intermediates

4-Alkylpyridines possessing nucleophilic β- dicarbonyl side chains have been converted to spirodihydropyridines upon treatment with ethyl chloroformate and sub-stoichiometric amounts of Ti(OiPr)4. Alternatively, inclusion of mild base in the reaction medium was found to facilitate generation of anhydrobase intermediates. Subsequent aldol-like condensations with electrophilic side chain moieties followed by hydrolysis delivered benzylically cyclized pyridines in good yield. In situ hydrogenation of cyclized anhydrobase intermediates afforded 4-substituted piperidines.