1400633-05-7

Basic information

• Product Name: 6-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrido[3,2-d]pyrimidin-4-amine
• Synonyms: 6-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrido[3,2-d]pyrimidin-4-amine
• CAS NO: 1400633-05-7
• Molecular Weight: 327.336
• Mol File: 1400633-05-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrido[3,2-d]pyrimidin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrido[3,2-d]pyrimidin-4-amine(1400633-05-7)
• EPA Substance Registry System: 6-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrido[3,2-d]pyrimidin-4-amine(1400633-05-7)

Safety Data

• Hazardous Substances Data: 1400633-05-7(Hazardous Substances Data)

Upstream product

• 1400633-17-1 4-chloro-6-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrido[3,2-d]pyrimidine 
• 1400633-16-0 4-chloro-6-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrido[3,2-d]pyrimidine 
• 1218935-59-1 (R)-(+)-2-(2,5-difluorophenyl)pyrrolidine 
• 171178-33-9 6-chloropyrido<3,2-d>pyrimidin-4(3H)-one 

Downstream Products

• 1400632-89-4 N-{6-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrido[3,2-d]pyrimidin-4-yl}-1-(morpholin-4-ylmethyl)cyclopropanecarboxamide 

Relevant articles and documents

TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF

The present invention is directed to quinazolinyl and pyridoquinazolinyl compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.