1400664-24-5

Basic information

• Product Name: C₂₇H₂₉N₃O₄
• Synonyms: C₂₇H₂₉N₃O₄
• CAS NO: 1400664-24-5
• Molecular Weight: 459.545
• Mol File: 1400664-24-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₇H₂₉N₃O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₇H₂₉N₃O₄(1400664-24-5)
• EPA Substance Registry System: C₂₇H₂₉N₃O₄(1400664-24-5)

Safety Data

• Hazardous Substances Data: 1400664-24-5(Hazardous Substances Data)

Upstream product

• 1373433-13-6 2-chloro-6-[3-methoxy-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-5H-pyrrolo[3,4-b]pyridin-7(6H)-one 
• 5720-07-0 4-methoxyphenylboronic acid 
• 2287-10-7 1-[2-(2-methoxy-4-nitrophenoxy)ethyl]pyrrolidine 
• 394248-90-9 3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)aniline 
• 7250-67-1 1-(2-chloroethyl)pyrrolidine hydrochloride 
• 100200-99-5 potassium 2-methoxy-4-nitrophenolate monohydrate 
• 1201924-34-6 methyl 3-(bromomethyl)-6-chloropicolinate 
• 59718-84-2 3-methyl-pyridine-2-carboxylic acid methyl ester 
• 878207-92-2 methyl 6-chloro-3-methyl-pyridine-2-carboxylate 
• 878207-91-1 methyl 3-methyl-1-oxido-pyridin-1-ium-2-carboxylate 

Relevant articles and documents

Synthesis and SAR study of pyrrolo[3,4-b]pyridin-7(6H)-one derivatives as melanin concentrating hormone receptor 1 (MCH-R1) antagonists

The discovery and optimization of novel pyrrolo[3,4-b]pyridin-7(6H)-one MCH-R1 antagonists are described. A systematic SAR study probing the effects of aryl-, benzyl- and arylthio-substituents at the 2-position of the pyrrolo[3,4-b]pyridin-7(6H)-ones led to identification of the 2-[(4-fluorophenyl)thio] derivative 7b as a highly potent MCH-R1 antagonist. This compound also has favorable pharmacokinetic properties along with a high metabolic stability and a minimal impact on CYP isoforms and hERG.