1400867-48-2 Usage
Description
HT-2 Toxin 4-Glucuronide is an analogue of HT-2 Toxin (H671800), a trichothecene group mycotoxin. It is derived from the 4-hydroxy analogue of T-2 Toxin (T002980) and is known for its ability to induce DNA damage and cell death upon prolonged administration.
Uses
Used in Pharmaceutical Industry:
HT-2 Toxin 4-Glucuronide is used as a research compound for studying the effects of trichothecene mycotoxins on cellular processes and their potential applications in drug development. Its ability to induce DNA damage and cell death makes it a valuable tool for understanding the mechanisms of action and developing countermeasures against these toxins.
Used in Toxicology Research:
HT-2 Toxin 4-Glucuronide is utilized as a model compound in toxicology research to investigate the toxic effects of trichothecene mycotoxins on various cell types and organisms. This helps in understanding the potential health risks associated with exposure to these toxins and developing strategies for their detection and mitigation.
Used in Agricultural Industry:
HT-2 Toxin 4-Glucuronide is employed as a reference material in the agricultural industry for the development and validation of analytical methods to detect and quantify trichothecene mycotoxins in crops and food products. This ensures the safety and quality of the food supply by monitoring and controlling the presence of these harmful substances.
Check Digit Verification of cas no
The CAS Registry Mumber 1400867-48-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,0,0,8,6 and 7 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1400867-48:
(9*1)+(8*4)+(7*0)+(6*0)+(5*8)+(4*6)+(3*7)+(2*4)+(1*8)=142
142 % 10 = 2
So 1400867-48-2 is a valid CAS Registry Number.
1400867-48-2Relevant articles and documents
HT-2 toxin 4-glucuronide as new T-2 toxin metabolite: Enzymatic synthesis, analysis, and species specific formation of T-2 and HT-2 toxin glucuronides by rat, mouse, pig, and human liver microsomes
Welsch, Tanja,Humpf, Hans-Ulrich
, p. 10170 - 10178,9 (2020/09/15)
Glucuronides of the mycotoxin T-2 toxin and its phase I metabolite HT-2 toxin are important phase II metabolites under in vivo and in vitro conditions. Since standard substances are essential for the direct quantitation of these glucuronides, a method for the enzymatic synthesis of T-2 and HT-2 toxin glucuronides employing liver microsomes was optimized. Structure elucidation by nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry revealed that besides T-2 toxin glucuronide and HT-2 toxin 3-glucuronide also the newly identified isomer HT-2 toxin 4-glucuronide was formed. Glucuronidation of T-2 and HT-2 toxin in liver microsomes of rat, mouse, pig, and human was compared and metabolites were analyzed directly by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). A distinct, species specific pattern of glucuronidation of T-2 and HT-2 toxin was observed with interesting interindividual differences. Until recently, glucuronides have frequently been analyzed indirectly by quantitation of the aglycone after enzymatic cleavage of the glucuronides by β-glucuronidase. Therefore, the hydrolysis efficiencies of T-2 and HT-2 toxin glucuronides using β-glucuronidases from Helix pomatia, bovine liver, and Escherichia coli were compared.
