1401810-95-4Relevant articles and documents
Addressing phototoxicity observed in a novel series of biaryl derivatives: Discovery of potent, selective and orally active phosphodiesterase 10A inhibitor ASP9436
Hamaguchi, Wataru,Masuda, Naoyuki,Miyamoto, Satoshi,Kikuchi, Shigetoshi,Narazaki, Fumie,Shiina, Yasuhiro,Seo, Ryushi,Amano, Yasushi,Mihara, Takuma,Moriguchi, Hiroyuki,Hattori, Kouji
, p. 3351 - 3367 (2015)
Abstract We synthesized several biaryl derivatives as PDE10A inhibitors to prevent phototoxicity of 2-[4-({[1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl]oxy}methyl)phenyl]quinoline (1) and found that the energy difference between the energy-minimized conform