1402062-68-3

Basic information

• Product Name: 5′-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2-deoxy-3′-thioinosyl 3′-S-acetate
• Synonyms: 5′-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2-deoxy-3′-thioinosyl 3′-S-acetate
• CAS NO: 1402062-68-3
• Molecular Weight: 612.706
• Mol File: 1402062-68-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5′-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2-deoxy-3′-thioinosyl 3′-S-acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 5′-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2-deoxy-3′-thioinosyl 3′-S-acetate(1402062-68-3)
• EPA Substance Registry System: 5′-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2-deoxy-3′-thioinosyl 3′-S-acetate(1402062-68-3)

Safety Data

• Hazardous Substances Data: 1402062-68-3(Hazardous Substances Data)

Upstream product

• 1402062-64-9 5′-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2′-deoxy-xylo-inosine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 890-38-0 2-deoxyinosine 
• 93778-57-5 9-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-1H-purin-6(9H)-one 

Downstream Products

• 1334533-59-3 5′-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2-deoxy-3′-thioinosine 
• 1334533-56-0 S-[5′-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2-deoxy-3′-thioinosinyl] O-(2-cyanoethyl) diisopropylamidothiophosphite 

Relevant articles and documents

A simple synthesis of 2-deoxy-3-thioinosine and its phosphorothioamidite

5-O-{[Bis(4-methoxyphenyl)(phenyl)methyl])-2-deoxy-3-thioinosine and its S-phosphorothioamidite were prepared in five and six steps, respectively, from commercially available 2-deoxyinosine. The key 3-thio intermediate was synthesized by two sequential configuration inversions: a one-pot oxidation/reduction reaction and an S reaction. This intermediate was readily converted into the target compound with a high yield. Compared with other methods, this synthetic strategy has the advantages of brief reaction steps, a relatively high overall yield, and regioselectivity for the configuration inversions. The products might be useful as intermediates for the preparation of new functionalized nucleosides. Georg Thieme Verlag Stuttgart · New York.