140235-40-1Relevant articles and documents
Stereoselective introduction of two chiral centers by a single diketoreductase: An efficient biocatalytic route for the synthesis of statin side chains
Wu, Xuri,Wang, Lili,Wang, Shuzhen,Chen, Yijun
experimental part, p. 305 - 308 (2010/09/09)
Statins, including atorvastatin (Lipitor), are the top-selling drugs in the world. The biocatalytic production of chiral side chains of statin drugs is of great interest to academia and industry. Stereoselective double reduction of a β,δ-diketo ester catalyzed by a diketoreductase offers a simple and efficient route for the preparation of statin side chains. Comparison of different cofactor regeneration systems resulted in an easy and cost-effective process for this enzymatic reduction.
2,4-DIHYDROXYADIPIC ACID DERIVATIVE
-
, (2008/06/13)
A novel 2,4-dihydroxyadipic acid derivative of the formula: STR1 wherein R1 and R4 are the same or different and each a hydrogen atom, an alkyl group, an aralkyl group, an aryl group or a silyl group, and R2 and R3 are the same or different and each a hydrogen atom or a protective group of a hydroxy group or together form a ring, which is useful as a common intermediate in the synthesis of HMG-CoA reductase inhibitor