1403383-57-2

Basic information

• Product Name: (Z)-ethyl-2-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy)acetate
• Synonyms: (Z)-ethyl-2-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy)acetate
• CAS NO: 1403383-57-2
• Molecular Weight: 402.444
• Mol File: 1403383-57-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (Z)-ethyl-2-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-ethyl-2-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy)acetate(1403383-57-2)
• EPA Substance Registry System: (Z)-ethyl-2-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy)acetate(1403383-57-2)

Safety Data

• Hazardous Substances Data: 1403383-57-2(Hazardous Substances Data)

Upstream product

• 117048-62-1 combrestatin A₄ 
• 105-36-2 ethyl bromoacetate 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 61240-20-8 triphenyl-(3,4,5-trimethoxybenzyl)phosphonium bromide 
• 21852-50-6 3,4,5-trimethoxybenzyl bromide 
• 3840-31-1 (3,4,5-trimethoxyphenyl)methanol 
• 121042-96-4 (E)-1-(3',4',5'-Trimethoxyphenyl)-2-(4''-methoxy-3''-tert-butyldimethylsiloxyphenyl)ethene 
• 82198-80-9 α-bromoethyl acetate 
• 121042-95-3 (Z)-5-(3-tert-butyldimethylsilyloxy-4-methoxystyryl)-1,2,3-trimethoxybenzene 
• 927-68-4 bromoethyl acetate 
• 121042-94-2 <3-<(tert-butyldimethylsilyl)oxy>-4-methoxybenzyl>triphenylphosphonium bromide 
• 97315-20-3 3-<(tert-butyldimethylsilyl)oxy>-4-methoxybenzyl bromide 
• 97315-19-0 3-<(tert-butyldimethylsilyl)oxy>-4-methoxybenzyl alkohol 
• 97315-18-9 p-methoxy-m-(tert-butyldimethylsilyloxy)-benzaldehyde 

Downstream Products

• 1392442-17-9 N₁-(6-methoxy-1,3-benzothiazol-2-yl)-2-{2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)-1-ethenyl]phenoxy}acetamide 
• 1392441-96-1 N₁-(6-(trifluoromethoxy)-1,3-benzothiazol-2-yl)-2-{2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)-1-ethenyl]phenoxy}acetamide 
• 1392441-94-9 N₁-(6-(trifluoromethyl)-1,3-benzothiazol-2-yl)-2-{2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)-1-ethenyl]phenoxy}acetamide 
• 763903-09-9 2-{2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)-1-ethenyl]phenoxy}acetic acid 
• 1392441-90-5 N₁-(1,3-benzothiazol-2-yl)-2-{2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)-1-ethenyl]phenoxy}acetamide 
• 1392441-92-7 N₁-(6-fluoro-1,3-benzothiazol-2-yl)-2-{2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)-1-ethenyl]phenoxy}acetamide 
• 1392442-15-7 N₁-(6-chloro-1,3-benzothiazol-2-yl)-2-{2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)-1-ethenyl]phenoxy}acetamide 

Relevant articles and documents

Synthesis of Combretastatin A-4 and 30-Aminocombretastatin A-4 derivatives with Aminoacid Containing Pendants and Study of their Interaction with Tubulin and as Downregulators of the VEGF, hTERT and c-Myc Gene Expression

Natural product combretastatin A-4 (CA-4) and its nitrogenated analogue 30-aminocombretastatin A-4 (AmCA-4) have shown promising antitumor activities. In this study, a range of CA-4 and AmCA-4 derivatives containing amino acid pendants have been synthesized in order to compare their biological actions with those of their parent compounds. Thus, inhibition of cell proliferation on tumor cell lines HT-29, MCF-7 and A-549, as well as on the nontumor cell line HEK-273; in vitro tubulin polymerization; mitotic cell arrest; action on the microtubule cell network and inhibition of VEGF, hTERT, and c-Myc genes have been evaluated. Some AmCA-4 derivatives bearing L-amino acids exhibited inhibition of cell proliferation at low nanomolar levels exceeding the values shown by AmCA-4. Furthermore, while CA-4 and AmCA-4 derivatives do not show significant effects on the in vitro tubulin polymerization and cell cycle arrest, some selected CA-4 and AmCA-4 derivatives are able to cause total depolymerization of the microtubule network on A-549 cells. The best results were obtained in the inhibition of gene expression, particularly on the VEGF gene, in which some AmCA-4 derivatives greatly exceeded the inhibition values achieved by the parent compound.

Amidobenzothiazoles And Process For The Preparation Thereof

The present invention provides a compound of general formulae A useful as potential anti-cancer agents against human cancer cell lines and a process for the preparation thereof. Where in R, R1, R2═H, alkyl, alkoxy, halo, haloalkyl, halomethoxy, nitro and G= Where in R, R1, R2═H, alkyl, alkoxy, halo, haloalkyl, halomethoxy, nitro and G=