14039-10-2 Usage
Description
1-(1-Adamantyl)-3-(2-chloroethyl)-3-nitrosourea, also known as ACNU, is a nitrosourea derivative with potential applications in cancer treatment. It functions as an alkylating agent, forming reactive alkyl groups that bind to DNA, causing DNA damage and cell death. ACNU has demonstrated the ability to cross the blood-brain barrier, making it a promising candidate for treating brain tumors and other cancers within the central nervous system.
Uses
Used in Anticancer Applications:
ACNU is used as a chemotherapeutic agent for the treatment of various types of cancer, particularly brain tumors. Its ability to cross the blood-brain barrier allows it to exert cytotoxic effects on tumor cells within the central nervous system. However, its clinical use is limited by potential toxic effects on normal tissues, such as bone marrow, necessitating further research to optimize its therapeutic potential.
Used in Pharmaceutical Research:
In the pharmaceutical industry, ACNU is used as a research compound for the development of new cancer treatments. Its unique properties, such as the ability to cross the blood-brain barrier and its alkylating action, make it a valuable tool in the search for more effective and targeted therapies against cancer.
Used in Drug Delivery Systems:
Similar to gallotannin, ACNU's limitations can be addressed by developing novel drug delivery systems. These systems aim to improve the delivery, bioavailability, and therapeutic outcomes of ACNU by employing various organic and metallic nanoparticles as carriers, enhancing its efficacy against cancer cells while minimizing toxic side effects on normal tissues.
Check Digit Verification of cas no
The CAS Registry Mumber 14039-10-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,0,3 and 9 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 14039-10:
(7*1)+(6*4)+(5*0)+(4*3)+(3*9)+(2*1)+(1*0)=72
72 % 10 = 2
So 14039-10-2 is a valid CAS Registry Number.
InChI:InChI=1/C13H20ClN3O2/c14-1-2-17(16-19)12(18)15-13-6-9-3-10(7-13)5-11(4-9)8-13/h9-11H,1-8H2,(H,15,18)
