140670-39-9Relevant articles and documents
Synthesis of Triacylglycerol from Polyunsaturated Fatty Acid by Immobilized Lipase
Kosugi, Yoshitsugu,Azuma, Naoki
, p. 1397 - 1403 (1994)
More than 95percent of polyunsaturated acid (PUFA) was converted to triacylglycerol by immobilized lipase from Candida antarctica or Rhizomucor miehei.The esterification was carried out at 50-60 deg C with shaking and dehydration for 24 h.The substrates consisted of glycerol and free fatty acid or ethyl esters of the fatty acid at a 1:3 molar ratio.The docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA) in the substrate polymerized during the reaction, and they required 5-10percent more than the stoichiometric amount to compensate for the PUFA loss.On the contrary, ethyl esters of DHA and EPA were not polymerized.Pure tridocosahexaenoyl, trieicosapentaenoyl and triarachidonoyl glycerol were isolated after passing the product through a basic aluminum oxide column.Industrial feasibility of this process was discussed for the ethyl ester as substrate. KEY WORDS: Docosahexaenoic acid, docosahexaenoyl ethyl ester, eicosapentaenoic acid, immobilized lipase, lipase, polyunsaturated fatty acid, triacylglycerol, triarachidonoyl glycerol, tridocosahexaenoyl glycerol, trieicosapentaenoyl glycerol.
Compositions and methods for the treatment of urea cycle disorders and gout
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, (2016/11/14)
The disclosures herein provide compounds of Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI and Formula VII or its pharmaceutical acceptable compositions and salts, as well as polymorphs, enantiomers, stereoisomers, solvates, and hydrates thereof. The pharmaceutical compositions may be formulated for oral administration, delayed release or sustained release, transmucosal, syrup, topical, parenteral administration, injection, subdermal, oral solution, rectal administration, nanoparticle, buccal administration or transdermal administration. Such compositions may be used to treatment of urea cycle disorders and gout or its associated complications.
POLYUNSATURATED FATTY ACID MONOGLYCERIDES, DERIVATIVES, AND USES THEREOF
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Page/Page column 22, (2008/12/08)
The invention emcompasses polyunsaturated fatty acid monoglycerides and derivatives thereof, having the formulae (I), (II), (III) and (IV), pharmaceutically acceptable salts thereof, compositions thereof and processes of preparing said compounds. These compounds can be useful as cancer chemopreventive agents, cancer treating agents, or radioenhencers for radiotherapy of cancer, or for inhibiting tumor growth or cell proliferation, or reducing tumor growth.
