140676-65-9

Basic information

• Product Name: 7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-5-hydroxy-10,10-dimethyl-1,2,4,10-tetrahydro-9-oxa-3-aza-phenanthrene-3-carboxylic acid tert-butyl ester
• Synonyms: 7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-5-hydroxy-10,10-dimethyl-1,2,4,10-tetrahydro-9-oxa-3-aza-phenanthrene-3-carboxylic acid tert-butyl ester
• CAS NO: 140676-65-9
• Molecular Weight: 495.634
• Mol File: 140676-65-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-5-hydroxy-10,10-dimethyl-1,2,4,10-tetrahydro-9-oxa-3-aza-phenanthrene-3-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-5-hydroxy-10,10-dimethyl-1,2,4,10-tetrahydro-9-oxa-3-aza-phenanthrene-3-carboxylic acid tert-butyl ester(140676-65-9)
• EPA Substance Registry System: 7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-5-hydroxy-10,10-dimethyl-1,2,4,10-tetrahydro-9-oxa-3-aza-phenanthrene-3-carboxylic acid tert-butyl ester(140676-65-9)

Safety Data

• Hazardous Substances Data: 140676-65-9(Hazardous Substances Data)

Upstream product

• 60926-09-2 8-[4-(4-fluoro-phenyl)-1-methyl-butyl]-5,5-dimethyl-1,3,4,5-tetrahydro-2H-chromeno[4,3-c]pyridin-10-ol 
• 58632-95-4 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile 

Downstream Products

• 140676-68-2 {7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-10,10-dimethyl-3-methylcarbamoylmethyl-2,3,4,10-tetrahydro-1H-9-oxa-3-aza-phenanthren-5-yloxy}-acetic acid ethyl ester 
• 140676-78-4 3-{7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-5-methoxy-10,10-dimethyl-1,2,4,10-tetrahydro-9-oxa-3-aza-phenanthren-3-yl}-propionic acid 
• 140676-74-0 7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-5-methoxy-10,10-dimethyl-2,3,4,10-tetrahydro-1H-9-oxa-3-aza-phenanthrene 
• 140676-69-3 5-Ethoxycarbonylmethoxy-7-[4-(4-fluoro-phenyl)-1-methyl-butyl]-10,10-dimethyl-1,2,4,10-tetrahydro-9-oxa-3-aza-phenanthrene-3-carboxylic acid tert-butyl ester 

Relevant articles and documents

Synthesis and structure-activity relationships of a series of novel benzopyran-containing platelet activating factor antagonists

A class of N-substituted tetrahydrobenzopyrano[3,4-c]pyridines, I, have been identified as antagonists of platelet activating factor (PAF). The structural features essential for PAF binding were determined by systematic modification of three sites in the molecule. While O-alkyl analogues had little affect on binding potency, N-alkyl analogues exhibited a wide range of activity. Structural changes in the core ring system generally resulted in a loss of binding activity. Optimization of the N- and O-substituents resulted in the analogues 25-27 which exhibited K(i) values ranging between 131 and 167 nM in a [3H]PAF binding assay. Compound 23 was also active in a model of PAF-induced shock in the mouse following intravenous administration.