140711-81-5

Basic information

• Product Name: 2-(3-methyl-1H-1,2,4-triazol-1-yl)-1-trityloxypropan-3-ol
• CAS NO: 140711-81-5
• Molecular Weight: 399.492
• Mol File: 140711-81-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(3-methyl-1H-1,2,4-triazol-1-yl)-1-trityloxypropan-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-methyl-1H-1,2,4-triazol-1-yl)-1-trityloxypropan-3-ol(140711-81-5)
• EPA Substance Registry System: 2-(3-methyl-1H-1,2,4-triazol-1-yl)-1-trityloxypropan-3-ol(140711-81-5)

Safety Data

• Hazardous Substances Data: 140711-81-5(Hazardous Substances Data)

Upstream product

• 7170-01-6 3-methyl-1H-[1,2,4]triazole 
• 126272-25-1 1-dimethyl-tert-butylsilyloxy-3-trityloxypropan-2-ol 
• 76-83-5 trityl chloride 
• 16975-62-5 tritylglycerol 

Relevant articles and documents

A novel class of platelet activating factor (PAF) antagonists. II. Modification of the 2-position of the glycerol backbone of PAF-sulfonamide isosteres

In a continuing effort to obtain more potent platelet activating factor (PAF) antagonists, we tried to synthesize a series of PAF-sulfonamide isosteres in which the substituent at the 2-position was modified to an acetoxy equivalent other than the methoxy group. These modifications produced highly active PAF antagonists. Compound 3-[2-(5-methyl-2H-tetrazol-2-yl)-3-(octadecylcarbamoyloxy)propylaminosu lfonyl]propylquinolinium iodide (52) showed the most potent activity in the in vitro inhibitory effect on PAF-induced platelet aggregation in rabbit platelet-rich plasma (IC50 = 125 nm) and also in the in vivo protective effect on PAF-induced lethality in mice, with prolonged duration of action. Optically active enantiomers of this compound were synthesized and the (S)-(-)-isomer (IC50 = 87 nM) was found to be three times more potent that the (R)-(+)-isomer (IC50 = 289nM), clearly exemplifying the enantioselectivity in the PAF-antagonist action of this novel compound.