1407189-73-4

Basic information

• Product Name: C₂₂H₂₄N₂O₃
• CAS NO: 1407189-73-4
• Molecular Weight: 364.444
• Mol File: 1407189-73-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₄N₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₄N₂O₃(1407189-73-4)
• EPA Substance Registry System: C₂₂H₂₄N₂O₃(1407189-73-4)

Safety Data

• Hazardous Substances Data: 1407189-73-4(Hazardous Substances Data)

Upstream product

• 1417826-05-1 C₁₈H₁₇NO₃ 
• 3433-37-2 piperidin-2-ylmethanol 
• 153274-63-6 ethyl (indolizine-2-carboxylate) 
• 109-06-8 α-picoline 

Relevant articles and documents

Discovery of novel pyrrolopyridazine scaffolds as transient receptor potential vanilloid (TRPV1) antagonists

A novel indolizine class of compounds was identified as TRPV1 antagonist from an HTS campaign. However, this indolizine class proved to be unstable and reacted readily with glutathione when exposed to light and oxygen. Reactivity was reduced by the introduction of a nitrogen atom alpha to the indolizine nitrogen. The pyrrolopyridazine core obtained proved to be inert to the action of light and oxygen. The synthesis route followed the one used for the indolizine compounds, and the potency and ADMET profile proved to be similar.