14088-99-4 Usage
General Description
1-(4-Chlorophenyl)-2-imidazolidinone, also known as lonidamine, is a synthetic chemical compound with a molecular formula of C9H8ClN3O. It has been studied for its potential antineoplastic and chemosensitizing effects. Lonidamine has been shown to inhibit various enzymes and processes involved in cancer cell metabolism and growth, making it a candidate for use in cancer treatment. Additionally, it has been investigated for its ability to enhance the effectiveness of chemotherapy drugs by increasing their uptake and retention in cancer cells. However, lonidamine has also been associated with certain side effects, including gastrointestinal disturbances and potential reproductive toxicity, which may limit its clinical use. Overall, this compound has shown promise as a potential therapeutic agent for cancer treatment, but further research is needed to fully understand its safety and efficacy.
Check Digit Verification of cas no
The CAS Registry Mumber 14088-99-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,0,8 and 8 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 14088-99:
(7*1)+(6*4)+(5*0)+(4*8)+(3*8)+(2*9)+(1*9)=114
114 % 10 = 4
So 14088-99-4 is a valid CAS Registry Number.
InChI:InChI=1/C9H9ClN2O/c10-7-1-3-8(4-2-7)12-6-5-11-9(12)13/h1-4H,5-6H2,(H,11,13)
14088-99-4Relevant articles and documents
Nucleophilic substitution of azide acting as a pseudo leaving group: One-step synthesis of various aza heterocycles
Doebelin, Christelle,Schmitt, Martine,Antheaume, Cyril,Bourguignon, Jean-Jacques,Bihel, Frederic
, p. 11335 - 11341 (2013/12/04)
The reaction of 3-azidopropanoic acid with the carbodiimide-based coupling reagent DIC leads to a six-membered-ring intermediate acting as a versatile precursor to a diverse set of aza heterocycles, including mono-, bi-, and tricyclic compounds.
Design and efficient synthesis of novel arylthiourea derivatives as potent hepatitis C virus inhibitors
Kang, Iou-Jiun,Wang, Li-Wen,Hsu, Sheng-Ju,Lee, Chung-Chi,Lee, Yen-Chun,Wu, Yen-Shian,Yueh, Andrew,Wang, Jing-Chyi,Hsu, Tsu-An,Chao, Yu-Sheng,Chern, Jyh-Haur
scheme or table, p. 6063 - 6068 (2010/06/13)
A novel class of arylthiourea HCV inhibitors bearing various functionalities, such as cyclic urea, cyclic thiourea, urea, and thiourea, on the alkyl linker were designed and synthesized. Herein we report the synthesis and structure-activity relationships