141112-29-0 Usage
Description
Isoxaflutole is a 4-benzoyl isoxazole molecule used as a preand early post-emergence herbicide for the control of a wide range of important broadleaf and grass weeds in maize (Zea mays) in both Europe and North America. It is also registered for use in sugarcane in Central and South America. Isoxaflutole works by inhibiting the enzyme 4-Hydroxyphenylpyruvate dioxygenase (HPPD), which results in the disruption of pigment biosynthesis, leading to characteristic bleaching of newly developed tissues of susceptible species, followed by growth cessation and necrosis.
Uses
Used in Agriculture:
Isoxaflutole is used as a herbicide for controlling a wide range of broadleaf and grass weeds in maize and sugar cane. It is effective against both grass and broad-leaved weeds, providing selective control and enhancing crop yield and quality.
Used in Maize (Zea mays) Cultivation:
Isoxaflutole is used as a preand early post-emergence herbicide in maize cultivation, marketed as Balance for corn (maize) in the United States and Merlin for corn in Europe. It helps in controlling weeds that compete with maize plants for resources, thus promoting healthier growth and increased productivity.
Used in Sugarcane Cultivation:
Isoxaflutole is registered for use in sugarcane cultivation in Central and South America. It is effective in controlling weeds that affect sugarcane growth, leading to improved sugarcane yield and quality.
Used in Combination with Other Herbicides:
Isoxaflutole mixes well with other herbicides such as metolachlor, acetochlor, dimethenamid, and atrazine, providing a comprehensive weed control spectrum and allowing for reduced application rates of the latter compounds.
Used in Controlling Triazine-resistant Weeds:
Isoxaflutole is effective in controlling triazine-resistant weeds in the field, offering an alternative solution for farmers dealing with herbicide-resistant weed populations.
Pharmacology
Isoxaflutole is readily taken up by roots and foliar
tissues and then rapidly degraded to a diketonitrile derivative
(2-cyclopropyl-3-(2-mesyl-4-trifluoromethylphenyl)-
3-oxo propanenitrile) , which is translocated
throughout the plant via xylem and phloem (2,3,6,8). It
is this metabolite that inhibits HPPD (7), thereby depleting
the plastoquinone pools in developing leaves. Plastoquinone
is a cofactor in the desaturation of phytoene, levels
of which increase in bleached leaves, concomitant with
decreases in colored carotenoids (6). Although bleaching
is the primary symptom associated with HPPD inhibition,
subsequent growth suppression and necrosis are also
believed to be a consequence (8).
Isoxaflutole also degrades to the diketonitrile derivative
in the soil (3,8). The half-life of isoxaflutole in soil
is dependent on soil type, pH, and moisture, ranging
from 12 hours to 3 days under laboratory conditions (8).
The physicochemical properties of isoxaflutole and of
diketonitrile play an important role in both soil and
herbicidal activity and selectivity (8).
Check Digit Verification of cas no
The CAS Registry Mumber 141112-29-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,1,1 and 2 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 141112-29:
(8*1)+(7*4)+(6*1)+(5*1)+(4*1)+(3*2)+(2*2)+(1*9)=70
70 % 10 = 0
So 141112-29-0 is a valid CAS Registry Number.
InChI:InChI=1/C15H12F3NO4S/c1-24(21,22)12-6-9(15(16,17)18)4-5-10(12)13(20)11-7-19-23-14(11)8-2-3-8/h4-8H,2-3H2,1H3
141112-29-0Relevant articles and documents
Isoxaflutole synthesizing method
-
, (2017/08/28)
The invention discloses an isoxaflutole synthesizing method. According to the method, 2-nitro-4-trifluoromethylbenzonitrile serves as an initial raw material; and isoxaflutole is formed through methylthiolation, catalytic oxidation, condensation, hydrolysis, enolization and a ring-closure reaction. The synthesizing route provided in the method is reasonable; the conversion rate of each step is high; generated intermediates are high in purity; all the intermediates do not need further purification treatment; the process is simple; and the total yield of the isoxaflutole is greater than 73%, and HPLC purity is greater than 98%.
A method for the preparation of isoxazole compounds (by machine translation)
-
Paragraph 0067; 0069; 0071; 0076, (2017/08/26)
The invention belongs to the field of chemical synthesis, discloses a the isoxazole compounds are of the formula (2) as shown by a compound, the method comprising: in the presence of organic solvent, of formula (1) shown in contact with the water and hydroxylamine compound. The method of the invention without requiring the use of capture can be prepared under the conditions of high purity and high yield of formula (2) shown in the isoxazole compounds. (by machine translation)
Dicarbonyl aromatic compound and its preparation method and two carbonyl aromatic composition and method for the preparation of isoxazole compounds
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Paragraph 0119, (2016/11/28)
Belonging to the field of chemical synthesis, the invention discloses a dicarbonyl aromatic compound shown as formula (1) or its enol form tautomer and a preparation method thereof. The method includes contacting the compound shown as formula (2) with water in the presence of an organic solvent. The invention also discloses a dicarbonyl aromatic composition and a preparation method of an isoxazole compound shown as formula (3). The method includes contacting the compound shown as formula (1) and/or its enol form tautomer with hydroxylamine. The method provided by the invention can prepare high purity and high yield isoxazole compound shown as formula (3) without using an acid-binding agent. (formula (1), formula (2) and formula (3)).
