1412429-43-6Relevant articles and documents
Three-component reactions of CF3-substituted boranes, ethyl diazoacetate and imines
Elkin, Pavel K.,Levin, Vitalij V.,Dilman, Alexander D.,Struchkova, Marina I.,Arkhipov, Dmitry E.,Korlyukov, Alexander A.
supporting information, p. 6216 - 6218,3 (2021/10/12)
Aryl(methoxy)(trifluoromethyl)boranes, generated in situ, readily react with ethyl diazoacetate and N-(4- methoxyphenyl)imines to give derivatives of β-amino acids. In this process, the electron-deficient borane reacts with the diazo compound followed by trapping of the intermediate boron enolate by the imine. The final products are predominantly produced as syn isomers.
