1415663-96-5

Basic information

• Product Name: C₂₃H₁₇F₃N₆OS
• Synonyms: C₂₃H₁₇F₃N₆OS
• CAS NO: 1415663-96-5
• Molecular Weight: 482.489
• Mol File: 1415663-96-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₁₇F₃N₆OS(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₁₇F₃N₆OS(1415663-96-5)
• EPA Substance Registry System: C₂₃H₁₇F₃N₆OS(1415663-96-5)

Safety Data

• Hazardous Substances Data: 1415663-96-5(Hazardous Substances Data)

Upstream product

• 614750-82-2 1-(6-methylpyridin-2-yl)-2-[1,2,4]triazolo-[1,5-a]pyridin-6-yl-ethanone 
• 198649-68-2 2-(trifluoromethoxy)benzyl bromide 
• 1415663-76-1 4-(6-methylpyridin-2-yl)-5-([1,2,4]triazolo[1,5-a]-pyridin-6-yl)thiazol-2-amine 
• 614750-81-1 [1,2,4]-triazolo[1,5-a]pyridine-6-carbaldehyde 
• 1415663-75-0 2-bromo-1-(6-methylpyridin-2-yl)-2-([1,2,4]triazolo[1,5-a]-pyridin-6-yl)ethanone 

Relevant articles and documents

Synthesis and biological evaluation of 2-benzylamino-4(5)-(6-methylpyridin- 2-yl)-5(4)-([1,2,4]triazolo[1,5-a]-pyridin-6-yl)thiazoles as transforming growth factor-β type 1 receptor kinase inhibitors

A series of 2-benzylamino-4(5)-(6-methylpyridin-2-yl)-5(4)-([1,2,4] triazolo[1,5-a]pyridin-6-yl)thiazoles 12a-ab, 13a, 13b, and 18a-d has been synthesized and evaluated for their ALK5 inhibitory activity in an enzyme assay and in a cell-based luciferase reporter assay. The N-(3-fluorobenzyl)-4-(6- methylpyridin-2-yl)-5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)thiazol-2-amine (12b) inhibited ALK5 phosphorylation with an IC50 value of 7.01 nM and showed 61% inhibition at 30 nM in a luciferase reporter assay using HaCaT cells permanently transfected with p3TP-luc reporter construct.