14167-18-1Relevant articles and documents
Catalyst for synthesizing benzenediol, and preparation method and application thereof
-
Paragraph 0014; 0027-0031, (2021/10/27)
The invention relates to a catalyst for synthesizing benzenediol, and a preparation method and application thereof. The complex is composed of EDTA -salicylaldehyde bis-amine Schiff base which is complexed with metal ions. The preparation method comprises the following steps: firstly dropping the second amine into an ethanol solution of salicylaldehyde, and heating and refluxing. Washing, drying to give bis salicylaldehyde bis-amine Schiff base and mixing with any ratio EDTA to form a bidentate ligand. Then, the double-ligand preparation solution is added dropwise into the central ion solution, and the EDTA -salicylaldehyde condensed diamine Schiff base metal complex composite catalyst is prepared by heating, refluxing, washing and drying. The composite catalyst is used for phenol hydrogen peroxide hydroxylation reaction and phenol conversion rate _AOMARKENCODEGTX0AOA 30%, Benzenediol selectivity-AOMARKENCODEGTX0AOA 90 -93%.
Oxidative Desulfurization of Dibenzothiophene Using Cobalt (II) Complexes with Substituted Salen-Type Ligands as Catalysts in Model Fuel Oil
Tripathi, Deependra,Singh, Raj K.
, p. 713 - 719 (2020/08/06)
Three cobalt(II)-salen complexes (CoL1, CoL2 and CoL3) were synthesized via the reaction of the three tetradentate ligands as N,N′-ethylenebis(salicylimine) L1, N,N′-ethylenebis(3-tert-butylsalicylimine) L2 and N,N′-ethylenebis(3,5-di-tert-butylsalicylimine) L3, with a stoichiometric amount of cobalt(II) acetate tetrahydrate, respectively. All the three complexes were studied as oxidative desulfurization catalyst on dibenzothiophene taken in model fuel oil n-dodecane. The acetonitrile used as an extracting solvent and H2O2 as an oxidant. Comparatively CoL3 proved to be the best catalyst which showed the 76% DBT removal at the optimized conditions. The nth-order kinetic model is the best way to represent oxidation kinetics of complexes. Graphic Abstract: [Figure not available: see fulltext.]This cobalt(II) Schiffs base complexes were studied as catalyst for oxidative desulfurization of dibenzothiphene (DBT) taken as model sulphur compounds in fuel model oil (n-dodecane) using H2O2 as oxidant and acetonitrile as extracting solvent for DBT sulfone in a batch experiment.
Potential application of two cobalt (III) Schiff base complexes in cancer chemotherapy: Leads from a study using breast and lung cancer cells
Gowdhami, Balakrishnan,Ambika, Subramanian,Karthiyayini, Balakrishnan,Ramya, Venkatesan,Kadalmani, Balamuthu,Vimala,Akbarsha, Mohammad A.
, (2021/07/12)
Cobalt (III) Schiff base complexes are of attraction in the context of their potential application in cancer therapy. The aim of this study has been to find the mechanism of action of cobalt (III) Schiff base complexes 1 and 2, the synthesis and characterization of which have already been reported, in inhibiting growth of human breast cancer cell MCF-7 and lung cancer cell A549. The already proclaimed anti-proliferative effect of the cobalt complexes was ascertained using MTT cytotoxicity assay. More assays such as Acridine orange & Ethidium bromide staining, AnnexinV-Cy3 staining, Hoechst staining, comet assay, and Reactive Oxygen Species (ROS) assay- all supported the cytotoxic property of the complexes. Moreover, the expression levels of mRNA of pro- and antiapoptotic genes also supported the effectiveness of cobalt complexes by modifying the ratio of Bax: Bcl-2. In addition, the cobalt complexes induced apoptosis in MCF- 7 and A549 cells through modulation of pro-apoptotic, anti-apoptotic, and ROS modulatory gene expressions. The present study validates the scientific evidence for antiproliferative efficacy of cobalt complexes against MCF-7 and A549 cells. Thus, this study takes cobalt complexes 1 and 2 to a step higher towards their use as anticancer agents.