141732-76-5 Usage
Description
Exenatide acetate is a 39-amino acid peptide originally isolated from the salivary glands of the Gila monster (Heloderma suspectum). It differs from exendin-3 only in two positions close to the N-terminus and is a white solid. As an incretin mimetic, exenatide acetate acts as an agonist of the glucagon-like peptide-1 (GLP-1) receptor, similar to GLP-1 but with prolonged activity. It increases the postprandial production of insulin and suppresses the secretion of glucagon.
Uses
Used in Pharmaceutical Industry:
Exenatide acetate is used as a medication for the treatment of type II diabetes. As an incretin mimetic, it acts as an agonist of the GLP-1 receptor, increasing acinar cAMP without stimulating amylase release. This leads to an augmentation of postprandial insulin production and suppression of glucagon secretion, making it a valuable treatment option for managing blood sugar levels in patients with type II diabetes.
Clinical Use
39-peptide known as an incretin mimetic;
an agonist of glucagon-like peptide-1,
used adjunctively in type II diabetes
mellitus.
Drug interactions
Potentially hazardous interactions with other drugs
Anticoagulants: possibly enhances anticoagulant
effect of warfarin.
Other nephrotoxins: avoid concomitant use.
Metabolism
Exenatide is eliminated through the kidneys by
glomerular filtration followed by proteolytic degradation.
Check Digit Verification of cas no
The CAS Registry Mumber 141732-76-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,7,3 and 2 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 141732-76:
(8*1)+(7*4)+(6*1)+(5*7)+(4*3)+(3*2)+(2*7)+(1*6)=115
115 % 10 = 5
So 141732-76-5 is a valid CAS Registry Number.
