1417820-89-3Relevant articles and documents
NMP and O2 as Radical Initiator: Trifluoromethylation of Alkenes to Tertiary β-Trifluoromethyl Alcohols at Room Temperature
Liu, Chao,Lu, Qingquan,Huang, Zhiyuan,Zhang, Jian,Liao, Fan,Peng, Pan,Lei, Aiwen
, p. 6034 - 6037 (2015)
A novel strategy was developed to trigger ·CF3 by using in situ generated peroxide in NMP under O2 or air as the radical initiator. Radical trifluoromethylation of alkenes was achieved toward tertiary β-trifluoromethyl alcohols. Various tertiary β-trifluoromethyl alcohols can be synthesized in good yields without extra oxidants or transition metal catalysts. Preliminary mechanistic investigation revealed that O2 diffusion can influence the reaction rate.
Cobalt-Tertiary-Amine-Mediated Hydroxytrifluoromethylation of Alkenes with CF3Br and Atmospheric Oxygen
Li, Qiankun,Fan, Wu,Peng, Deqian,Meng, Bingyin,Wang, Shaohan,Huang, Rui,Liu, Shihao,Li, Suhua
, p. 4012 - 4018 (2020/05/05)
The mild and efficient hydroxytrifluoromethylation of alkenes with bromotrifluoromethane (CF3Br) and atmospheric oxygen mediated by cobalt-tertiary amine is described. This reaction proceeds with broad substrate scope and good functional group compatibility. Mechanistic studies indicate that the reaction proceeds through a radical pathway, which is enabled by combination of the previously unexplored highly efficient N-isopropyl-N,2-dimethylpropan-2-amine with Co(II) for the single electron reduction of CF3Br to CF3 radical.
A facile method for hydroxytrifluoromethylation of alkenes with Langlois reagent and DMSO
Shen, Wei-Guo,Wu, Qing-Yan,Gong, Xing-Yu,Ao, Gui-Zhen,Liu, Feng
supporting information, p. 2983 - 2987 (2019/06/18)
A practical hydroxytrifluoromethylation of alkenes using the Langlois reagent as the trifluoromethyl source and DMSO as the oxidant is described. This reaction is mild and operationally simple, without exclusion of either moisture or oxygen, allowing access to a wide range of β-trifluoromethyl alcohols in useful yields. This transformation is environmentally friendly and can be easily scaled up to gram level.