141929-48-8Relevant articles and documents
6-PEPTIDYLAMINO-1-NAPHTHALENESULFONAMIDES USEFUL AS FLUOROGENIC PROTEOLYTIC ENZYME SUBSTRATES
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, (2008/06/13)
The present invention encompasses compounds of formula I: STR1 and the pharmaceutically acceptable non-toxic salts thereof; wherein R 1 is hydrogen, lower alkyl, alkenyl, alkynyl, cycloalkyl, alkylcycloalkyl, cycloalkylalkyl, or phenylalkyl;R 2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, alkylcycloalkyl, cycloalkylalkyl, or phenylalkyl; orNR 1 R 2 forms a nitrogen heterocycle; andR 3 is hydrogen, an amino acid or a peptide residue.These compounds may be employed as substrates in assays for determining proteolytic enzyme activity or as enzyme inhibitors. The invention also encompasses methods for determining proteolytic enzyme activity using the compounds of formula I.