1422438-36-5

Basic information

• Product Name: C₂₂H₂₁FN₆
• CAS NO: 1422438-36-5
• Molecular Weight: 388.447
• Mol File: 1422438-36-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₁FN₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₁FN₆(1422438-36-5)
• EPA Substance Registry System: C₂₂H₂₁FN₆(1422438-36-5)

Safety Data

• Hazardous Substances Data: 1422438-36-5(Hazardous Substances Data)

Upstream product

• 860626-80-8 (4-fluoropyridin-3-yl)boronic acid 
• 23056-47-5 2-bromo-4-methyl-5-nitropyridine 

Relevant articles and documents

Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors

Pim kinase inhibitors are promising cancer therapeutics. Pim-2, among the three Pim isoforms, plays a critical role in multiple myeloma yet inhibition of Pim-2 is challenging due to its high affinity for ATP. A co-crystal structure of a screening hit 1 bound to Pim-1 kinase revealed the key binding interactions of its indazole core within the ATP binding site. Screening of analogous core fragments afforded 1H-pyrazolo[3,4-c]pyridine (6-azaindazole) as a core for the development of pan-Pim inhibitors. Fragment and structure based drug design led to identification of the series with picomolar biochemical potency against all three Pim isoforms. Desirable cellular potency was also achieved.