14225-79-7

Basic information

• Product Name: 1H-BENZIMIDAZOLE, 2-(2,4-DICHLOROPHENYL)-
• Synonyms: 1H-BENZIMIDAZOLE, 2-(2,4-DICHLOROPHENYL)-;2-(2,4-Dichlorophenyl)-1H-benzimidazole
• CAS NO: 14225-79-7
• Molecular Formula: C₁₃H₈Cl₂N₂
• Molecular Weight: 263.13
• Mol File: 14225-79-7.mol
• Article Data: 59

Chemical Properties

• Boiling Point: 448.4°Cat760mmHg
• Flash Point: 257.5°C
• Appearance: /
• Density: 1.427g/cm³
• Vapor Pressure: 3.1E-08mmHg at 25°C
• Refractive Index: 1.697
• CAS DataBase Reference: 1H-BENZIMIDAZOLE, 2-(2,4-DICHLOROPHENYL)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-BENZIMIDAZOLE, 2-(2,4-DICHLOROPHENYL)-(14225-79-7)
• EPA Substance Registry System: 1H-BENZIMIDAZOLE, 2-(2,4-DICHLOROPHENYL)-(14225-79-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 14225-79-7(Hazardous Substances Data)

Usage

General Description

1H-Benzimidazole, 2-(2,4-dichlorophenyl)-, also known as omeprazole, is a chemical compound used in the treatment of gastroesophageal reflux disease (GERD) and other conditions caused by excess stomach acid production. It works by inhibiting the proton pump in the stomach lining, reducing the amount of acid produced. Omeprazole is a widely prescribed medication and is available over-the-counter in some countries. It is generally well-tolerated, but may have some side effects such as headache, diarrhea, and nausea. It is important to follow the prescribed dosage and recommendations of a healthcare professional when using this chemical.

InChI:InChI=1/C13H8Cl2N2/c14-8-5-6-9(10(15)7-8)13-16-11-3-1-2-4-12(11)17-13/h1-7H,(H,16,17)

Upstream product

• 874-42-0 2,4-dichlorobenzaldeyhde 
• 95-54-5 1,2-diamino-benzene 
• 50-84-0 2,4 dichlorobenzoic acid 
• 1777-82-8 (2,4-dichlorophenyl)methanol 
• 95-00-1 2,4-dichloro-benzenemethanamine 
• 5330-43-8 N-<(2,4-dichlorophenyl)methylene>benzamine 
• 56843-28-8 2,4-dichlorobenzaldoxime 
• 2234-16-4 1-(2,4-dichlorophenyl)ethan-1-one 
• 20443-99-6 2,4-dichlorobenzyl bromide 

Downstream Products

• 1081111-20-7 2-(2,4-dichlorophenyl)-1-{3-[4-(3-acetylaminophenyl)piperidin-1-yl]propyl}-1H-benzimidazole 

Relevant articles and documents

Efficient synthesis of 2-aryl-1-arylmethyl-1H-benzimidazoles in ball mill without solvent

2-Aryl-1-arylmethyl-1H-benzimidazoles were prepared in excellent yields by the condensation of o-phenylenediamine with aldehydes under mechanically activated solvent-free conditions in ball mill using FeCl3· 6H2O as the catalyst.

p-Toluenesulfonic acid coated natural phosphate as an efficient catalyst for the synthesis of 2-substituted benzimidazole

2-Substituted benzimidazoles are selectively synthesised in high yields via the condensation of o-phenylenediamine derivatives with aldehyde derivatives using catalytic amount of p-toluenesulfonic acid coated natural phosphate (NP/PTSA) under mild conditions. The use of NP/PTSA as a reusable catalyst makes this process simple, convenient, and environmentally friendly.

Eco-friendly synthesis of 2-substituted benzimidazoles using air as the oxidant

A simple, environmentally friendly procedure for the synthesis of 2-substituted benzimidazoles by the one-pot condensation of o-phenylenediamines with aromatic aldehydes using continuous bubbling of air in absolute ethanol at room temperature is described. The simplicity of the system, mild conditions, involvement of a non-toxic and practically inexhaustible oxidant, easy and quick isolation of the products, and moderate to good yields are the main advantages of this procedure.

Improved convenient and environmentally benign synthesis of biological active benzimidazoles using activated carbon and molecular oxygen

The reaction of 1,2-phenylenediamine with a variety of aromatic aldehydes in xylenes gave the corresponding benzimidazole derivatives in good to excellent yields (82-93%) in the presence of dry activated carbon and bubbling molecular oxygen. The present r

Syntheses, characterization, and catalytic potential of novel vanadium and molybdenum Schiff base complexes for the preparation of benzimidazoles, benzoxazoles, and benzothiazoles under thermal and ultrasonic conditions

A new ONO-tridentate Schiff base ligand (H2L) derived from 3-methoxysalicylaldehyde and nicotinic hydrazide was synthesized and characterized by elemental analysis, FT-IR, 1H NMR, 13C NMR, UV–Vis, and powder XRD studies. Then, oxovanadium(V) and dioxomolybdenum(VI) Schiff base complexes, VOL and MoO2L, were also prepared and characterized by different techniques. Moreover, the catalytic activities of both complexes were investigated for the synthesis of benzimidazoles, benzoxazoles, and benzothiazoles under reflux conditions as well as through ultrasonic irradiation. The results revealed several advantages of this procedure, including high product yields, short reaction times, facile work-up procedure, simplicity in operation, eco-friendly reaction conditions, and green aspects by avoiding toxic catalysts and solvents. Graphic abstract: [Figure not available: see fulltext.]

One-pot Synthesis of Benzimidazoles Using H2SO4@HTC as Catalyst

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