14252-05-2

Basic information

• Product Name: Bicyclo[3,2,1]octane-3-one
• Synonyms: Bicyclo[3,2,1]octane-3-one;Bicyclo[3.2.1]octan-3-one;3-Bicyclo[3.2.1]octanone;Bicyclo[3.2.1]octan-3-one95+%
• CAS NO: 14252-05-2
• Molecular Formula: C₈H₁₂O
• Molecular Weight: 124.18028
• Mol File: 14252-05-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 139 °C
• Boiling Point: 201.6°C at 760 mmHg
• Flash Point: 68.7°C
• Appearance: /
• Density: 1.039g/cm³
• Vapor Pressure: 0.305mmHg at 25°C
• Refractive Index: 1.499
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: Bicyclo[3,2,1]octane-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: Bicyclo[3,2,1]octane-3-one(14252-05-2)
• EPA Substance Registry System: Bicyclo[3,2,1]octane-3-one(14252-05-2)

Safety Data

• Hazardous Substances Data: 14252-05-2(Hazardous Substances Data)

Usage

Description

Bicyclo[3,2,1]octane-3-one is a unique organic compound characterized by its bicyclic structure and a ketone functional group. It is known for its potential applications in various chemical and pharmaceutical processes due to its distinct molecular properties.

Uses

Used in Pharmaceutical Industry:
Bicyclo[3,2,1]octane-3-one is used as a reactant for the synthesis of polycyclic acid derivatives, which serve as selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1). This application is significant because 11β-HSD-1 plays a crucial role in various metabolic and inflammatory diseases, and its inhibition can lead to the development of novel therapeutic strategies for conditions such as type 2 diabetes, obesity, and cardiovascular diseases.

InChI:InChI=1/C8H12O/c9-8-4-6-1-2-7(3-6)5-8/h6-7H,1-5H2

Upstream product

• 823-02-9 bicyclo[3.2.1]oct-2-ene 
• 35242-17-2 3-chlorobicyclo<3.2.1>oct-2-ene 
• 77419-23-9 2,2-bis(methylthio)bicyclo<3.2.1>octan-3-one 
• 68197-21-7 Bicyclo<3.2.1>octan-3-yl-phenylketon 
• 497-38-1 Norbornan-2-on 
• 18084-03-2 2-exo-ethynylbicyclo<2.2.1>heptan-2-ol 
• 2394-47-0 exo-3,4-dichlorobicyclo<3.2.1>oct-2-ene 
• 77412-88-5 (1R,2S,4S)-2-(Tris-methylsulfanyl-methyl)-bicyclo[2.2.1]heptan-2-ol 
• 938-05-6 dibromamine-B 
• 498-66-8 norborn-2-ene 
• 57615-42-6 3,4-dichlorobicyclo[3.2.1]oct-2-ene 
• 51788-41-1 3-bromo-2,6-bicyclo<3.2.1>octatriene 
• 123-25-1 succinic acid diethyl ester 
• 4176-66-3 3-bromobicyclo<3,2,1>oct-2-ene 

Downstream Products

• 4877-39-8 3-Methylen-bicyclo<3.2.1>octan 
• 92-51-3 cyclohexylcyclohexane 
• 13387-10-5 bicyclo[3.2.1]octanol-3 
• 13387-09-2 exo-bicyclo[3.2.1]octan-3-ol 
• 269064-09-7 (+/-)-O-1231 
• 269064-07-5 2-Carbomethoxy-3-phenyl-bicyclo(3.2.1)-2-octene 
• 269064-08-6 2-carbomethoxy-3-(4-fluorophenyl)-bicyclo(3.2.1)-2-octene 

Relevant articles and documents

Bicyclo[3.2.1]octanes: Synthesis and inhibition of binding at the dopamine and serotonin transporters

Herein we report the synthesis of a series of bicyclo[3.2.1]octanes and their binding characteristics at the dopamine and serotonin transporters. The data confirm that a heteroatom at position 8 of the tropane nucleus is not a prerequisite for binding since the bicyclo[3.2.1]octanes prove potent inhibitors of both transporters. Therefore the three-dimensional topology of the ligand may be more important than specific functionality with respect to stereospecific binding at the acceptor site.

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COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS

Compounds represented by formula (I) : or pharmaceutically acceptable salts and solvates thereof, wherein R1, X, Y, Y1, and Z are as defined herein, are useful for treating flavivi?dae viral infections Said viral infection is Hepatitis C virus (HCV), bovme viral diarrhea virus (BVDV), hog cholera virus, dengue fever virus, Japanese encephalitis virus or yellow fever virus

Ring expansions of 2-haloethynyl-2-norbornanols

2-Haloethynyl-2-norbornanols react with iodine and Koser's reagent in acetonitrile to afford two ring-expanded products, 2-[(Z)-haloiodomethylidene]bicyclo[3.2.1]octan-3-one and 3-[(Z)-haloiodomethylidene]bicyclo[3.2.1]octan-2-one. These results contrast with the 2-haloethynyl-2-bornanols which lead to the corresponding 3-octanones.