14259-47-3

Basic information

• Product Name: DIDYMIN
• Synonyms: (S)-7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-methoxyphenyl)-4H-benzopyran-4-one;Iso-sakuranetin-7-putinoside;(s)-5,7-dihydroxy-4'-methoxyflavanone-7-β-rutinoside;DIDYMIN WITH HPLC;DIDYMIN hplc;Isosakuranetin, (S)-5,7-Dihydroxy-4μ-methoxyflavanone-7-β-rutinoside;(S)-7-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one;4'-Methoxy-5,7-dihydroxyflavanone-7-o-rutinoside
• CAS NO: 14259-47-3
• Molecular Formula: C28H34O14
• Molecular Weight: 594.56
• EINECS: 238-139-6
• Product Categories: Flavanones
• Mol File: 14259-47-3.mol
• Article Data: 0

Chemical Properties

• Melting Point: 211-213°C
• Boiling Point: 896.6 °C at 760 mmHg
• Flash Point: 295.3 °C
• Appearance: faintly beige powder
• Density: 1.59 g/cm³
• Vapor Pressure: 1.47E-34mmHg at 25°C
• Refractive Index: 1.677
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Sparingly), Methanol (Slightly, Heated, Sonicated)
• PKA: 7.17±0.40(Predicted)
• Stability: Hygroscopic
• BRN: 1361217
• CAS DataBase Reference: DIDYMIN(CAS DataBase Reference)
• NIST Chemistry Reference: DIDYMIN(14259-47-3)
• EPA Substance Registry System: DIDYMIN(14259-47-3)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 14259-47-3(Hazardous Substances Data)

Usage

Description

DIDYMIN, also known as Dihydromyricetin, is a naturally occurring flavonoid compound found in the fruit of the Vitis amurensis grapevine. It is known for its various biological activities, including antioxidant, anti-inflammatory, and hepatoprotective properties. DIDYMIN has gained attention for its potential therapeutic applications in various health conditions.

Uses

Used in Pharmaceutical Industry:
DIDYMIN is used as a therapeutic agent for its hepatoprotective properties, helping to protect and repair liver cells from damage caused by toxins, alcohol, and viral infections. It is particularly useful in the treatment of liver diseases such as alcoholic hepatitis, drug-induced liver injury, and viral hepatitis.
Used in Nutraceutical Industry:
DIDYMIN is used as a dietary supplement for its antioxidant and anti-inflammatory effects. It can help reduce oxidative stress and inflammation in the body, which may contribute to the prevention of chronic diseases and the promotion of overall health.
Used in Cosmetic Industry:
DIDYMIN is used as an active ingredient in cosmetic products for its potential anti-aging and skin protective properties. It may help improve skin elasticity, reduce the appearance of wrinkles, and protect the skin from environmental stressors.
Used in Anticancer Applications:
Similar to Neoponcirin, DIDYMIN has been shown to exhibit anticancer properties by targeting various cellular pathways involved in cancer cell growth and survival. It may be used as a chemopreventive agent or in combination with conventional cancer therapies to enhance their efficacy and reduce side effects.

InChI:InChI=1/C28H34O14/c1-11-21(31)23(33)25(35)27(39-11)38-10-19-22(32)24(34)26(36)28(42-19)40-14-7-15(29)20-16(30)9-17(41-18(20)8-14)12-3-5-13(37-2)6-4-12/h3-8,11,17,19,21-29,31-36H,9-10H2,1-2H3/t11-,17?,19+,21-,22+,23+,24-,25+,26+,27?,28+/m0/s1

Related news

DIDYMIN (cas 14259-47-3) induces apoptosis through mitochondrial dysfunction and up-regulation of RKIP in human hepatoma cells07/21/2019

In the present study, a flavonoid was isolated from Origanum vulgare and identified as didymin. The effect and mechanism of O. vulgare didymin (OVD) on human HepG2 liver carcinoma cell was then assessed. Our results showed that OVD strongly inhibited the viability, clonogenicity and migration of...detailed

DIDYMIN (cas 14259-47-3) ameliorates hepatic injury through inhibition of MAPK and NF-κB pathways by up-regulating RKIP expression07/19/2019

A flavone was isolated from Origanum vulgare and identified as didymin (O. vulgare didymin, OVD). The protective effect and mechanism of OVD on acute liver injury was then assessed in vivo and in vitro. Our results showed that OVD significantly alleviated CCl4-induced liver injury in mice and ma...detailed

DIDYMIN (cas 14259-47-3) prevents hyperglycemia-induced human umbilical endothelial cells dysfunction and death07/17/2019

Although didymin, a flavonoid-O-glycosides compound naturally found in the citrus fruits, has been reported to be a potent anticancer agent in the prevention of various cancers, its role in the prevention of cardiovascular complications is unclear. Most importantly, its effect in the prevention ...detailed

DIDYMIN (cas 14259-47-3) by suppressing NF-κB activation prevents VEGF-induced angiogenesis in vitro and in vivo07/16/2019

Although didymin, a dietary flavonoid glycoside from citrus fruits, known to be a potent antioxidant with anti-cancer activities, its role in angiogenesis is not known. In this study, we examined the effect of didymin on VEGF-induced angiogenesis in vitro and in vivo models. Our results suggest ...detailed