142618-92-6

Basic information

• Product Name: Boc-D-tert-Leucinol
• Synonyms: Boc-D-tert-Leucinol;N-Boc-D-tert-leucinol
• CAS NO: 142618-92-6
• Molecular Weight: 217.309
• Mol File: 142618-92-6.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Boc-D-tert-Leucinol(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-D-tert-Leucinol(142618-92-6)
• EPA Substance Registry System: Boc-D-tert-Leucinol(142618-92-6)

Safety Data

• Hazardous Substances Data: 142618-92-6(Hazardous Substances Data)

Usage

General Description

Boc-D-tert-Leucinol is a chemical compound extensively used in the field of pharmaceuticals and biochemistry as a substrate for the synthesis of various drug molecules. It contains a Boc, or tert-butyloxycarbonyl group, which is an important protecting group in organic synthesis which provides protection for an amine, especially in peptide synthesis. The Leucinol part refers to the presence of a leucine, an essential amino acid needed for protein synthesis in the body. Not much information is available regarding its physical or toxic properties, although it would be sensible to handle it as a potentially harmful material and follow standard laboratory safety protocols.

Upstream product

• 26782-71-8 D-tert-leucine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 3907-02-6 (2R)-2-amino-3,3-dimethylbutan-1-ol 
• 124655-17-0 (R)-2-(tert-butoxycarbonylamino)-3,3-dimethylbutanoic acid 
• 142618-89-1 (4R, 5S)-4-tert-butyl-5-(1,2-bis(isopropoxycarbonyl)hydrazino)-2-oxazolidinone 
• 153960-35-1 N-Boc-D-tert-leucine methyl ester 
• 31469-15-5 1-methoxy-2-methyl-1-trimethylsiloxy-1-propene 

Downstream Products

• 124655-17-0 (R)-2-(tert-butoxycarbonylamino)-3,3-dimethylbutanoic acid 
• 142618-93-7 (R)-(+)-4-tert-butyloxazolidin-2-one 
• 1313705-92-8 tert-butyl (R)-4-(tert-butyl)-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide 

Relevant articles and documents

Versatile routes to chiral 4-substituted 2-oxazolindinones and α-amino acids. Use of chiron, [4 + 2] cycloadducts of dialkyl azodi-carboxylates and 2-oxazolones

The thermal reaction of 3-[(1S)-2-alkoxy-1-apocamphanecarbonyl]-2-oxazolones with dialkyl azodicarboxylates results in exclusive formation of [4 + 2] type cycloadducts with moderate levels of diastereofacial selection, which serve as versatile chiral synthons for a wide variety of 4-alkyl and 4-alkyl-2-oxazolidinones as well as α-amino acids.

Crystal Form of Hepatitis B Surface Antigen Inhibitor

The present invention discloses a crystal form of a hepatitis B surface antigen inhibitor and a preparation method therefor, and also comprises the use of the crystal form in preparing the hepatitis B surface antigen inhibitor.

Asymmetric Multicomponent Sulfa-Michael/Mannich Cascade Reaction: Synthetic Access to 1,2-Diamino-3-Organosulfur Compounds and 2-Nitro Allylic Amines

A novel catalytic asymmetric three-component intermolecular sulfa-Michael/Mannich cascade reaction has been developed using a chiral multifunctional catalyst. This reaction provides facile access to 1-amino-2-nitro-3-organosulfur compounds bearing three c

The first synthesis of β-amino phosphonates using cyclic sulfamidates

Cyclic sulfamidates (prepared from α-amino acids and β-amino alcohols) have been used for the first time for the synthesis of novel β-amino phosphonates (chiral and achiral) by treatment with dialkyl phosphites using sodium hydride. 2-Substituted and 1,2-disubtituted β-amino phosphonates have efficiently been prepared following this method. The products are formed in high yield (79-84%) within 8-12 h.