14282-78-1Relevant articles and documents
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Blanchette,Brown
, p. 1848 (1952)
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Flash carboxylation: Fast lithiation-carboxylation sequence at room temperature in continuous flow
Pieber, Bartholomaeus,Glasnov, Toma,Kappe
, p. 13430 - 13433 (2014)
A method for the direct lithiation of terminal alkynes and heterocycles with subsequent carboxylation in a continuous flow format was developed. This method provides carboxylic acids at ambient conditions within less than five seconds with only little excess of the organometallic base and CO2. This journal is the Partner Organisations 2014.
Dianions of Methylated Thiophene-2-carboxylic Acids: Their Formation and Reactivity
Gould, Norman P.,Lee, Ta-Jyh
, p. 4528 - 4530 (1980)
Methylated thiophene-2-carboxylic acids can be readily homologated by treatment with LDA (2 equiv) followed by the addition of carbon-containing electrophiles.
Correlation of the rates of solvolyses of 4-methylthiophene-2-carbonyl chloride using the extended grunwald-winstein equation
Choi, Hojune,Koo, In Sun
scheme or table, p. 499 - 504 (2012/05/19)
The specific rates of sovolysis of 4-methylthiophene-2-carbonyl chloride (1) have been determined in 26 pure and binary solvents at 25.0 °C. Product selectivities are reported for solvolyses of 1 in aqueous ethanol and methanol binary mixtures. Comparison of the specific rates of solvolyses of 1 with those for p-methoxybenzoyl chloride (2) in terms of linear free energy relationships (LFER) are helpful in mechanistic considerations, as is also treatment in terms of the extended Grunwald-Winstein equation. It is proposed that the solvolyses of 1 in binary aqueous solvent mixtures proceed through an SN1 and/or ionization (I) pathway rather than through an associative S2 and/or addition-elimination (A-E) pathway.
RAF KINASE INHIBITORS
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Page/Page column 20-21, (2008/12/06)
Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.