142820-94-8 Usage
Description
Cytidine, 3'-azido-2',3'-dideoxy-5'-O-(triphenylmethyl)is a synthetic nucleoside analog with potential antiviral and antineoplastic activities. It is structurally similar to the building blocks of DNA and RNA, but with azido and dideoxy modifications that make it a potent inhibitor of viral replication, specifically targeting reverse transcriptase. The triphenylmethyl group enhances its stability and pharmacokinetic properties, making it a promising candidate for the development of novel antiviral and anticancer drugs.
Uses
Used in Pharmaceutical Industry:
Cytidine, 3'-azido-2',3'-dideoxy-5'-O-(triphenylmethyl)is used as an antiviral agent for its ability to inhibit viral replication by targeting reverse transcriptase. Its unique structure allows it to be a potent inhibitor, making it a valuable asset in the development of new antiviral drugs.
Used in Oncology Research:
Cytidine, 3'-azido-2',3'-dideoxy-5'-O-(triphenylmethyl)is used as an antineoplastic agent due to its potential to inhibit cancer cell growth and proliferation. Its unique modifications and improved stability make it a promising candidate for the development of novel anticancer drugs, offering new treatment options for various types of cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 142820-94-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,2,8,2 and 0 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 142820-94:
(8*1)+(7*4)+(6*2)+(5*8)+(4*2)+(3*0)+(2*9)+(1*4)=118
118 % 10 = 8
So 142820-94-8 is a valid CAS Registry Number.
142820-94-8Relevant articles and documents
Synthesis and antileukemic activity of chymotrygsin-activated derivatives of 3'-amino-2',3'-dideoxycytidine. (Synthetic nucleosides and nucleotides. XXXIII
Kawaguchi,Sakairi,Kimura,Yamaguchi,Saneyoshi
, p. 501 - 504 (2007/10/02)
3'-Amino-2',3'-dideoxycytidine (8) was directly synthesized from 2'-deoxycytidine, 2',3'-Dideoxy-3'-(N-acyl-L-phenylalanylamino)cytidines (acyl =butoxycarbonyl (9a), acetyl (9b), benzoyl (9c), and α-hexanoyl (9d)) were synthesized as chymotrypsin-activated prodrugs of 8. This N-protection was required for activation by chymotrypsin to 8. In vitro, compound 8 showed high cytotoxic activity against P388 cells, but the prodrugs 9a-d were ineffective. In vitro, however, these prodrugs showed much higher activity than 8 in mice bearing P388 cells.
