142874-81-5

Basic information

• Product Name: 2,2,4,6,7-Pentamethyldihydrobenzofuran
• Synonyms: 2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN;2,2,4,6,7-Pentamethyldihydrobenzofurane;2,2,4,6,7-pentamethyl-3a,4-dihydro-3H-1-benzofuran
• CAS NO: 142874-81-5
• Molecular Formula: C13H18O
• Molecular Weight: 190.28
• Mol File: 142874-81-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 268.739 °C at 760 mmHg
• Flash Point: 110.618 °C
• Appearance: /
• Density: 0.967g/cm³
• Vapor Pressure: 0.012mmHg at 25°C
• Refractive Index: 1.514
• CAS DataBase Reference: 2,2,4,6,7-Pentamethyldihydrobenzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,4,6,7-Pentamethyldihydrobenzofuran(142874-81-5)
• EPA Substance Registry System: 2,2,4,6,7-Pentamethyldihydrobenzofuran(142874-81-5)

Safety Data

• Hazardous Substances Data: 142874-81-5(Hazardous Substances Data)

Usage

Description

2,2,4,6,7-Pentamethyldihydrobenzofuran, also known as 2,3-Dihydro-2,2,4,6,7-pentamethylbenzofuran, is a chemical compound belonging to the 2,3-Dihydrobenzofuran family. It is characterized by its unique molecular structure with five methyl groups attached to the benzene ring and a dihydrobenzofuran moiety. 2,2,4,6,7-Pentamethyldihydrobenzofuran is known for its potential applications in various industries due to its chemical properties.

Uses

Used in Pharmaceutical Industry:
2,2,4,6,7-Pentamethyldihydrobenzofuran is used as an intermediate in the synthesis of various medicines. Its unique chemical structure allows it to be a key component in the development of new drugs with potential therapeutic applications.
Used in Agricultural Chemicals Industry:
In the agricultural chemicals industry, 2,2,4,6,7-Pentamethyldihydrobenzofuran is utilized as an intermediate for the production of various agrochemicals. Its chemical properties make it suitable for the development of new compounds with potential applications in pest control, crop protection, and other agricultural practices.

InChI:InChI=1/C13H18O/c1-8-6-9(2)11-7-13(4,5)14-12(11)10(8)3/h6H,7H2,1-5H3

Upstream product

• 697-82-5 2,3,5-trimethylphenol 
• 78-84-2 isobutyraldehyde 
• 142874-36-0 2,3,5-Trimethyl-1-(2-methyl-2-propenyloxy)benzene 
• 142874-43-9 2,3,5-trimethyl-6-(2-methylprop-2-en-1-yl)phenol 

Downstream Products

• 154445-78-0 2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-sulfonyl chloride 
• 1243545-39-2 1-(2,4-dimethoxyphenyl)-4-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine 
• 1243545-91-6 1-(3,4-dimethoxyphenyl)-4-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine 
• 1243545-96-1 1-(4-fluorophenyl)-4-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine 
• 1243545-86-9 1-(4-chlorophenyl)-4-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine 
• 1243546-81-7 4-[4-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)piperazin-1-yl]benzonitrile 

Relevant articles and documents

Discovery of Benzofuran Derivatives that Collaborate with Insulin-Like Growth Factor 1 (IGF-1) to Promote Neuroprotection

A series of benzofuran derivatives with neuroprotective activity in collaboration with IGF-1 was discovered using a newly developed cell-based assay involving primary neural cells prepared from rat hippocampal and cerebral cortical tissues. A structure-ac

2,2,4,6,7-Pentamethyl-2,3-dihydrobenzofuran-5-methyl (Pbfm) as an alternative to the trityl group for the side-chain protection of cysteine and asparagine/glutamine

The benzyl derivative of the Pbf group, which is the most commonly used side-chain protecting group for Arg, has been proposed for the protection of the side chains of Cys, Asp, and Glu. In the three cases, the new protecting group (Pbfm) was removed with a high concentration of TFA during the cleavage and global deprotection step. In addition, the Pbfm group can be removed from the Cys residue by using very dilute TFA solutions. Furthermore, when Cys is protected with the Pbfm group, it can be removed by oxidative treatment, thereby directly rendering the disulfide bridge on the solid phase.

UNEXPECTED IODINE CATALYZED CYCLIZATION FOR SYNTHESIS OF 2,2-DIALKYL-2,3-DIHYDROBENZOFURANS

2-(β-Methylallyl)phenol and 2-isobutenylphenol derivatives were easily cyclized to 2,2-dimethyl-2,3-dihydrobenzofurans in the presence of a catalytic amount of iodine without any formation of iodinated products.