143-27-1 Usage
Description
1-Hexadecylamine, also known as palmitamine, is a white waxy solid with an ammonia-like odor. It is insoluble in water and less dense than water, causing it to float on the surface. Due to its chemical properties, it may cause irritation to the skin, eyes, and mucous membranes, and it has the potential to be toxic through ingestion, inhalation, or skin absorption. It is primarily used to produce other chemicals.
Uses
Used in Chemical Production:
1-Hexadecylamine is used as a precursor for the production of various chemicals, including resins, senior detergents, and anti-caking agents. Its chemical properties make it a versatile compound in the chemical industry.
Used in Dental Caries Prophylactic:
1-Hexadecylamine is utilized in the development of dental caries prophylactic agents, contributing to the prevention and treatment of tooth decay.
Used in Resin Production:
1-Hexadecylamine is used as a component in the production of resins, which are essential materials in various industries such as plastics, coatings, and adhesives.
Used in Detergent Manufacturing:
1-Hexadecylamine is employed in the manufacturing of senior detergents, enhancing their cleaning properties and effectiveness.
Used in Anti-Caking Agent Production:
1-Hexadecylamine is used as a key ingredient in the production of anti-caking agents, which are additives that prevent the formation of lumps or clumps in powdered or granular products.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
HEXADECANAMINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Health Hazard
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.
Flammability and Explosibility
Notclassified
Purification Methods
Crystallise the base from thiophene-free *benzene and dry under vacuum over P2O5. Store away from CO2 [Beilstein 4 IV 818.]
Check Digit Verification of cas no
The CAS Registry Mumber 143-27-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,4 and 3 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 143-27:
(5*1)+(4*4)+(3*3)+(2*2)+(1*7)=41
41 % 10 = 1
So 143-27-1 is a valid CAS Registry Number.
InChI:InChI=1/C16H35N.C2H4O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17;1-2(3)4/h2-17H2,1H3;1H3,(H,3,4)
143-27-1Relevant articles and documents
Direct Enzymatic Synthesis of Fatty Amines from Renewable Triglycerides and Oils
Bevinakatti, Han,Citoler, Joan,Finnigan, William,Turner, Nicholas J.
, (2021/11/30)
Fatty amines represent an important class of commodity chemicals which have broad applicability in different industries. The synthesis of fatty amines starts from renewable sources such as vegetable oils or animal fats, but the process has multiple drawbacks that compromise the overall effectiveness and efficiency of the synthesis. Herein, we report a proof-of-concept biocatalytic alternative towards the synthesis of primary fatty amines from renewable triglycerides and oils. By coupling a lipase with a carboxylic acid reductase (CAR) and a transaminase (TA), we have accomplished the direct synthesis of multiple medium and long chain primary fatty amines in one pot with analytical yields as high as 97 %. We have also performed a 75 mL preparative scale reaction for the synthesis of laurylamine from trilaurin, obtaining 73 % isolated yield.
A biocatalytic cascade for the conversion of fatty acids to fatty amines
Citoler, Joan,Derrington, Sasha R.,Galman, James L.,Bevinakatti, Han,Turner, Nicholas J.
supporting information, p. 4932 - 4935 (2019/09/30)
Fatty amine synthesis from renewable sources is an energetically-demanding process involving toxic metal catalysts and harsh reaction conditions as well as selectivity problems. Herein we present a mild, biocatalytic alternative to the conventional amination of fatty acids through a one-pot tandem cascade performed by a carboxylic acid reductase (CAR) and a transaminase (ω-TA). Saturated and unsaturated fatty acids, with carbon chain lengths ranging from C6 to C18, were successfully aminated obtaining conversions of up to 96%.
A protic ionic liquid catalyzed strategy for selective hydrolytic cleavage of tert-butyloxycarbonyl amine (N-Boc)
Majumdar, Swapan,De, Jhinuk,Chakraborty, Ankita,Roy, Dipanwita,Maiti, Dilip K.
, p. 3200 - 3205 (2015/02/03)
A simple, mild and efficient strategy for selective hydrolytic cleavage of the N-tert-butyloxycarbonyl (Boc) group is devised using a protic ionic liquid as an efficient catalyst. The deprotection reaction proceeded well for N-Boc protected aromatic, heteroaromatic, aliphatic compounds, and chiral amino acid esters and peptides. A wide range of labile protecting groups such as tert-butyl ester, tert-butyl ether, benzyloxycarbonyl (Cbz), TBDMS, O-Boc and S-Boc remained unaffected under the reaction conditions. This journal is