143-57-7 Usage
Description
PROTOVERATRINE A is an alkaloid derived from Veratrum album, which yields colorless crystals when dissolved in ethanol. It is laevorotatory with specific optical rotation values in different solvents. PROTOVERATRINE A dissolves in sulfuric acid, resulting in a blue color. The alkaloid can form a complex with maleic acid, which also yields colorless crystals with a melting point of 241.5°C. Upon alkaline hydrolysis, it breaks down into protoverine, two moles of acetic acid, one mole of (-)-methylbutyric acid, and one mole of (+)-2-hydroxy-2-methylbutyric acid. It is commercially available under the brand name Protalba by Marion Merrell Dow.
Uses
1. Used in Pharmaceutical Industry:
PROTOVERATRINE A is used as an active pharmaceutical ingredient for the treatment of various medical conditions. Its specific applications and reasons for use may vary depending on the formulation and intended therapeutic effects.
2. Used in Research and Development:
PROTOVERATRINE A serves as a valuable compound for scientific research, particularly in the fields of pharmacology, biochemistry, and natural product chemistry. It can be used to study the structure-activity relationships of alkaloids, their interactions with biological targets, and their potential applications in drug discovery and development.
3. Used in Quality Control and Standardization:
As a reference compound, PROTOVERATRINE A can be employed in the quality control and standardization of Veratrum album extracts and related products. This ensures the consistency, purity, and potency of these products, which is crucial for their safety and efficacy.
4. Used in Toxicological Studies:
Due to its complex chemical structure and potential biological activities, PROTOVERATRINE A can be utilized in toxicological studies to evaluate the safety and potential side effects of Veratrum album and its derivatives. This information is essential for the development of safe and effective pharmaceutical products.
5. Used in Educational Purposes:
PROTOVERATRINE A can be used as a teaching aid in academic institutions, particularly in courses related to natural products chemistry, pharmacology, and drug discovery. It provides students with a practical example of an alkaloid derived from a plant source and its various applications in the pharmaceutical and scientific fields.
References
Stoll, Seebeck., Helv. Chim. Acta, 36,718 (1953)
Check Digit Verification of cas no
The CAS Registry Mumber 143-57-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,4 and 3 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 143-57:
(5*1)+(4*4)+(3*3)+(2*5)+(1*7)=47
47 % 10 = 7
So 143-57-7 is a valid CAS Registry Number.
InChI:InChI=1/C41H63NO14/c1-10-20(4)34(46)55-33-28(45)27-23(18-42-17-19(3)12-13-25(42)38(27,9)49)24-16-39-32(40(24,33)50)30(53-22(6)44)29(52-21(5)43)31-36(39,7)15-14-26(41(31,51)56-39)54-35(47)37(8,48)11-2/h19-20,23-33,45,48-51H,10-18H2,1-9H3/t19-,20+,23-,24?,25-,26-,27+,28+,29-,30+,31-,32+,33-,36-,37?,38+,39-,40-,41-/m0/s1
