1431433-20-3

Basic information

• Product Name: C₂₆H₂₃N₃O₂
• Synonyms: C₂₆H₂₃N₃O₂
• CAS NO: 1431433-20-3
• Molecular Weight: 409.488
• Mol File: 1431433-20-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₆H₂₃N₃O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₆H₂₃N₃O₂(1431433-20-3)
• EPA Substance Registry System: C₂₆H₂₃N₃O₂(1431433-20-3)

Safety Data

• Hazardous Substances Data: 1431433-20-3(Hazardous Substances Data)

Upstream product

• 1431434-47-7 C₁₉H₁₆BrNO₄ 
• 878197-87-6 N,N-dimethyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2- yl)phenyl)methanamine 
• 1431434-77-3 C₁₇H₁₁BrN₂O₂ 

Relevant articles and documents

Nucleotide competing reverse transcriptase inhibitors: Discovery of a series of non-basic benzofurano[3,2-d]pyrimidin-2-one derived inhibitors

A HTS screen led to the identification of a benzofurano[3,2-d]pyrimidin-2- one core structure which upon further optimization resulted in 1 as a potent HIV-1 nucleotide competing reverse transcriptase inhibitor (NcRTI). Investigation of the SAR at N-1 allowed significant improvements in potency and when combined with the incorporation of heterocycles at C-8 resulted in potent analogues not requiring a basic amine to achieve antiviral activity. Additional modifications at N-1 resulted in 33 which demonstrated excellent antiviral potency and improved physicochemical properties.