143210-98-4Relevant articles and documents
Confined Singlet Oxygen in Mesoporous Silica Nanoparticles: Selective Photochemical Oxidation of Small Molecules in Living Cells
Nakamura, Takuma,Son, Aoi,Umehara, Yui,Ito, Takeo,Kurihara, Ryohsuke,Ikemura, Yuta,Tanabe, Kazuhito
, p. 1058 - 1066 (2016)
(Chemical Equation Presented) Chemical conversion of specific bioactive molecules by external stimuli in living cells is a powerful noninvasive tool for clarification of biomolecular interactions and to control cellular functions. However, in chaotic biological environments, it has been difficult to induce arbitrary photochemical reactions on specific molecules because of their poor molecular selectivity. Here we report a selective and nontoxic photochemical reaction system utilizing photoactivated mesoporous silica nanoparticles to control biological functions. Methylene blue modification within nanoparticle pores for photosensitization produced singlet oxygen confined to the pore that could mediate selective oxidation of small molecules without any damage to living cells. This intracellular photochemical system produced bioactive molecules in situ and remotely controlled the cell cycle phase. We also confirmed that this photoreaction could be applied to control cell cycle phase in tumor tissue transplanted in mice. The cell cycle phase in the cells in mice, to which our system was administered, was arrested at the G2/M phase upon photoirradiation. We demonstrate a simple and promising method for the exogenous conversion of an intracellular biomolecule to another functional compound.
Synthesis and characterization of new water soluble 9,10-anthraquinonе and evaluation of its antimicrobial activity
Yordanova, Stanislava,Vasileva-Tonkova, Evgenia,Staneva, Desislava,Stoyanov, Stanimir,Grabchev, Ivo
, p. 22 - 27 (2018)
The synthesis and characterization of a new cationic anthraquinone derivative (S3) soluble in water has been described. Its absorption characteristics in aqueous and N,N-dimethylformamide solutions have been determined. Аntimicrobial activity of the compound S3 was tested in vitro towards eight pathogenic bacteria and two yeasts strains. The results obtained suggest that the newly synthesized compound is effective in treating the relevant pathogens and is suitable in designing new effective antimicrobial preparations. Antimicrobial activity and release of S3 after its deposition on cotton fabric and incorporation into thin polylactid film have also been investigated.
Inducing apoptosis through upregulation of p53: structure–activity exploration of anthraquinone analogs
Agbowuro, Ayodeji A.,Anifowose, Abiodun,Lu, Wen,Tan, Chalet,Tripathi, Ravi,Wang, Binghe,Yang, Xiaoxiao
, p. 1199 - 1210 (2020/06/17)
We previously reported a series of p53-elevating anthraquinone compounds with considerable cytotoxicity for acute lymphoblastic leukemia (ALL) cells. To further develop this class of compounds, we examined the effect of a few key structural features on the anticancer structure–activity relationship (SAR) in ALL cells. The active analogs showed comparable cytotoxicity and upregulation of p53 but did not induce significant downregulation of MDM2 as seen with the lead compound AQ-101, indicating the importance of the anthraquinone core scaffold for MDM2 regulation. The result from the current study not only contributes to the SAR framework of these anthraquinone derivatives but also opens up new chemical space for further optimization work.
