1432731-26-4

Basic information

• Product Name: 4-(4-fluorophenyl)-7-[(4-formyl-1H-pyrazol-1-yl)methyl]quinoline-2-carbonitrile
• Synonyms: 4-(4-fluorophenyl)-7-[(4-formyl-1H-pyrazol-1-yl)methyl]quinoline-2-carbonitrile
• CAS NO: 1432731-26-4
• Molecular Weight: 356.359
• Mol File: 1432731-26-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-fluorophenyl)-7-[(4-formyl-1H-pyrazol-1-yl)methyl]quinoline-2-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-fluorophenyl)-7-[(4-formyl-1H-pyrazol-1-yl)methyl]quinoline-2-carbonitrile(1432731-26-4)
• EPA Substance Registry System: 4-(4-fluorophenyl)-7-[(4-formyl-1H-pyrazol-1-yl)methyl]quinoline-2-carbonitrile(1432731-26-4)

Safety Data

• Hazardous Substances Data: 1432731-26-4(Hazardous Substances Data)

Upstream product

• 1044278-41-2 7-methylquinoline-2-carbonitrile N-oxide 
• 220143-50-0 7-methylquinoline-2-carbonitrile 
• 4053-43-4 7-methylquinoline N-oxide 
• 612-60-2 7-methylquinoline 
• 179380-98-4 7-(bromomethyl)-4-(4-fluorophenyl)quinoline-2-carbonitrile 
• 35344-95-7 1H-pyrazole-4-carbaldehyde 
• 932369-61-4 4-(4-fluorophenyl)-7-methylquinoline-2-carbonitrile 
• 1044278-42-3 4-chloro-7-methylquinoline-2-carbonitrile 

Downstream Products

• 1432731-27-5 4-(4-fluorophenyl)-7-[(4-formyl-1H-pyrazol-1-yl)methyl]quinoline-2-carboxamide 
• 1432731-28-6 7-({4-[cyclopropyl(hydroxy)methyl]-1H-pyrazol-1-yl}methyl)-4-(4-fluorophenyl)quinoline-2-carboxamide 
• 1432728-85-2 7-{[4-(cyclopropylcarbonyl)-1H-pyrazol-1-yl]methyl}-4-(4-fluorophenyl)quinoline-2-carboxamide 

Relevant articles and documents

QUINOLINE CARBOXAMIDE AND QUINOLINE CARBONITRILE DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE

The present invention provides quinoline carboxamide and quinoline carbonitrile compounds of formula (I) wherein ring A, RQ, -L-, R1, n, R2, and R3 are as defined herein. The compounds of the invention are useful as non-competitive mGluR2 antagonists, or mGluR2 negative allosteric modulators (NAMs), and in methods of treating a patient (preferably a human) for diseases or disorders in which the mGluR2-NAM receptor is involved, such as Alzheimer's disease, cognitive impairment, schizophrenia and other mood disorders, pain disorders and sleep disorders, by administering to the patient a therapeutically effective amount of a compound of the invention, or a pharmaceutically acceptable salt thereof. The invention is also directed to pharmaceutical compositions comprising a compound of the invention, or a pharmaceutically acceptable salt thereof, (optionally in combination with one or more additional active ingredients), and a pharmaceutically acceptable carrier, and the use of the compounds and pharmaceutical compositions of the invention in the treatment of such diseases.