143289-00-3

Basic information

• Product Name: (+)-2-<<2-(camphanoylamino)ethoxy>methyl>-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine
• CAS NO: 143289-00-3
• Molecular Weight: 589.085
• Mol File: 143289-00-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (+)-2-<<2-(camphanoylamino)ethoxy>methyl>-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-2-<<2-(camphanoylamino)ethoxy>methyl>-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine(143289-00-3)
• EPA Substance Registry System: (+)-2-<<2-(camphanoylamino)ethoxy>methyl>-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine(143289-00-3)

Safety Data

• Hazardous Substances Data: 143289-00-3(Hazardous Substances Data)

Upstream product

• 88150-42-9 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 
• 39637-74-6 (1S)-(-)-camphanic chloride 

Relevant articles and documents

Determination of the absolute configuration of the active amlodipine enantiomer as (-)-S: A correction

The active (-) enantiomer of amlodipine was originally reported to have R configuration. This does not concur with other 1,4-dihydropyridines with known absolute configuration. This configuration has now been determined by X-ray structural analysis using (1S)-camphanic acid and (S)-2-methoxy-2- phenylethanol as chiral probes. Both determinations gave the S configuration for the amlodipine (-) enantiomer with the greater Ca-antagonistic activity.