143359-25-5

Basic information

• Product Name: (4S,5R)-(-)-(2'-chloroacetyl)-3,4-dimethyl-5-phenyl-2-imidazolidinone
• Synonyms: (4S,5R)-(-)-(2'-chloroacetyl)-3,4-dimethyl-5-phenyl-2-imidazolidinone
• CAS NO: 143359-25-5
• Molecular Weight: 266.727
• Mol File: 143359-25-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (4S,5R)-(-)-(2'-chloroacetyl)-3,4-dimethyl-5-phenyl-2-imidazolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (4S,5R)-(-)-(2'-chloroacetyl)-3,4-dimethyl-5-phenyl-2-imidazolidinone(143359-25-5)
• EPA Substance Registry System: (4S,5R)-(-)-(2'-chloroacetyl)-3,4-dimethyl-5-phenyl-2-imidazolidinone(143359-25-5)

Safety Data

• Hazardous Substances Data: 143359-25-5(Hazardous Substances Data)

Upstream product

• 112791-04-5 (4R,5S)-3,4-dimethyl-5-phenyl-imidazolidin-2-one 
• 79-04-9 chloroacetyl chloride 
• 92841-65-1 (4R,5S)-1,5-dimethyl-4-phenylimidazolidin-2-one 

Downstream Products

• 307304-37-6 (4S,5R)-(-)-1-(2'-azidoacetyl)-3,4-dimethyl-5-phenyl-2-imidazolidinone 
• 143396-13-8 (4S,5R)-1,5-Dimethyl-4-phenyl-3-(2-phenylsulfanyl-acetyl)-imidazolidin-2-one 
• 143359-24-4 (4R,5S)-1,5-Dimethyl-4-phenyl-3-(2-phenylsulfanyl-acetyl)-imidazolidin-2-one 
• 143359-27-7 (4R,5S)-1,5-Dimethyl-4-phenyl-3-((S)-3-phenyl-2-phenylsulfanyl-propionyl)-imidazolidin-2-one 
• 143359-41-5 (4S,5R)-1,5-Dimethyl-4-phenyl-3-((R)-3-phenyl-2-phenylsulfanyl-propionyl)-imidazolidin-2-one 
• 143359-29-9 (4S,5R)-1-((E)-(S)-5,9-Dimethyl-2-phenylsulfanyl-deca-4,8-dienoyl)-3,4-dimethyl-5-phenyl-imidazolidin-2-one 
• 143359-28-8 (4R,5S)-1,5-Dimethyl-3-((S)-5-methyl-2-phenylsulfanyl-hex-4-enoyl)-4-phenyl-imidazolidin-2-one 
• 307304-63-8 (2R,4'R,5'S)-2-amino-3-(3,4-dimethoxyphenyl)-1-(3',5'-dimethyl-2'-oxo-4'-phenyl-1'-imidazolydinyl)propan-1-one 
• 307304-38-7 (4R,5S)-(+)-1-[2'-(diphenylmethyleneamino)acetyl]-3,4-dimethyl-5-phenyl-2-imidazolidinone 
• 307304-62-7 tert-butyl (4R,4'R,5'S)-4-amino-5-(3',4'-dimethyl-2'-oxo-5'-phenyl-1'-imidazolydinyl)-5-oxopentanoate 
• 307304-64-9 (3'R,4S,5R)-1,5-dimethyl-4-phenyl-3-(1',2',3',4'-tetrahydro-3'-isoquinolinylcarbonyl)-2-imidazolidinone 
• 307304-61-6 (2R,4'R,5'S)-2-amino-1-(3',4'-dimethyl-2'-oxo-5'-phenyl-1'-imidazolydinyl)-4-penten-1-one 
• 307304-50-3 (2S,4'S,5'R)-2-amino-3-(1,3-benzodioxol-5-yl)-1-(3',4'-dimethyl-2'-oxo-5'-phenyl-1'-imidazolydinyl)propan-1-one 

Relevant articles and documents

A Practical and Efficient Large-Scale Preparation of (4R,58)-N-Propenoyl-1,5-dimethyl-4-phenylimidazolidin-2-one. A Simple Procedure for the Preparation of N-Acylimidazolidin-2-ones and N-Acylbornane 2,10-Sultams

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(4R,5S)-1,5-Dimethyl-4-phenylimidazolidin-2-one as a chiral auxiliary for the diastereoselective alkylation of a new iminic glycine derivative: Practical asymmetric synthesis of α-amino acids

The lithium enolate of enantiomerically pure N- [bis(methylthio)methylene] glycinate 11 derived from (4R,5S)-1,5-dimethyl-4- phenylimidazolidin-2-one reacts with alkyl halides giving the alkylated derivatives 12 with a high degree of control of the diastereoselectivity. These alkylated systems are easily hydrolyzed to the corresponding α-amino acids, the chiral auxiliary being recovered.