1435937-73-7Relevant articles and documents
Highly regioselective preparation of heteroaryl-magnesium reagents by using a Br/Mg exchange
S?mann, Christoph,Haag, Benjamin,Knochel, Paul
supporting information, p. 16145 - 16152 (2013/02/21)
Disubstituted thienyl-, furyl- and pyridylmagnesium derivatives are regioselectively prepared from a Br/Mg exchange of the corresponding dibromo compounds by using either iPrMgCl·LiCl or hindered arylmagnesium reagents, such as isitylmagnesium bromide·lithium chloride (isityl=2,4,6-triisopropyl-phenyl) complexed with a diamine ligand, in difficult cases. The selective functionalisations of these heterocyclic scaffolds by using Negishi cross-coupling reactions, acylations or addition to aldehydes were readily achieved.