143884-84-8

Basic information

• Product Name: 7-FLUORO-3-(HYDROXYIMINO)INDOLIN-2-ONE
• Synonyms: 7-FLUORO-3-(HYDROXYIMINO)INDOLIN-2-ONE;7-FLUORO-3-OXIME-1H-INDOLE-2,3-DIONE;7-Fluoro-3-(hydroxyimino)indolin-2-one 98%;7-Fluoro-3-(hydroxyimino)indolin-2-one98%;7-Fluoroisatin-3-oxime 98%;7-Fluoro-1H-indole-2,3-dione 3-oxime, 1,3-Dihydro-7-fluoro-3-(hydroxyimino)-2H-indol-2-one;7-Fluoroisatin-3-oxime98%
• CAS NO: 143884-84-8
• Molecular Formula: C₈H₅FN₂O₂
• Molecular Weight: 180.14
• Product Categories: blocks;FluoroCompounds;IndolesOxindoles
• Mol File: 143884-84-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 248-250
• Boiling Point: 395.9°Cat760mmHg
• Flash Point: 193.2°C
• Appearance: /
• Density: 1.62g/cm³
• Vapor Pressure: 6.56E-08mmHg at 25°C
• Refractive Index: 1.679
• Storage Temp.: Keep Cold
• CAS DataBase Reference: 7-FLUORO-3-(HYDROXYIMINO)INDOLIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-FLUORO-3-(HYDROXYIMINO)INDOLIN-2-ONE(143884-84-8)
• EPA Substance Registry System: 7-FLUORO-3-(HYDROXYIMINO)INDOLIN-2-ONE(143884-84-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 143884-84-8(Hazardous Substances Data)

Usage

General Description

7-Fluoro-3-(hydroxyimino)indolin-2-one is a chemical compound with the molecular formula C9H6FNO2. It is a heterocyclic compound containing a fluorine atom and a hydroxyimino functional group. 7-FLUORO-3-(HYDROXYIMINO)INDOLIN-2-ONE has potential pharmacological applications and is often used in research and development as a building block for the synthesis of other biologically active molecules. The presence of the fluorine atom adds unique properties to the compound, making it useful for drug design and discovery. The hydroxyimino group also gives this compound potential as a reactive functional group for further chemical modifications and derivatizations. Overall, 7-fluoro-3-(hydroxyimino)indolin-2-one is a versatile and important molecule in the field of medicinal chemistry and drug development.

InChI:InChI=1/C8H5FN2O2/c9-5-3-1-2-4-6(5)10-8(12)7(4)11-13/h1-3,13H,(H,10,11,12)

Upstream product

• 143884-76-8 N-(2-Fluoro-phenyl)-2-nitro-acetamide 
• 348-54-9 2-Fluoroaniline 
• 143884-65-5 (2-Fluoro-phenyl)-((E)-1-methylsulfanyl-2-nitro-vinyl)-amine 
• 349-24-6 N-(2-fluorophenyl)-2-(hydroxyimino)acetamide 
• 317-20-4 7-fluoro-1H-indole-2,3-dione 

Downstream Products

• 115661-37-5 2-amino-3-fluorobenzonitrile 

Relevant articles and documents

Copper-Catalyzed Carbonyl Group Controlled Coupling of Isatin Oximes with Arylboronic Acids To Prepare N-Aryloxindole Nitrones

A variety of (E)-N-aryloxindole nitrones were prepared in good to excellent yields by using a copper-catalyzed coupling reaction of isatin oximes and arylboronic acids under mild conditions. Various arylboronic acids that contain sensitive functional groups were tolerated in the transformation, and detailed studies show that the carbonyl group of the isatin oximes serves as a ligand to control the formation of the (E)-oxindole nitrones. This method to prepare (E)-N-aryloxindole nitrones was easily performed on a gram scale and efficiently used to synthesize estrone-derived oxindole nitrone in high yield.

Compounds and Uses Thereof - 848

This invention relates to novel compounds having the structural formula I below: and their pharmaceutically acceptable salts, tautomers or in vivo-hydrolysable precursors, compositions and methods of use thereof, wherein R1, R2, Rsu

Synthesis of isatin 3-oximes from 2-nitroacetanilides

2-Nitroacetanilides, prepared by alkaline hydrolysis of 1-arylamino-1-methylthio-2-nitroethenes, are converted into isatin (1H-indole-2,3-dione) 3-oximes by treatment with concentrated sulfuric acid or trifluoromethanesulfonic acid at room temperature.