14394-77-5Relevant articles and documents
First report of the application of simple molecular complexes as organo-catalysts for Knoevenagel condensation
Panja, Sumit Kumar,Dwivedi, Nidhi,Saha, Satyen
, p. 65526 - 65531 (2015)
A series of molecular complexes have been designed, synthesized and used as organo-catalysts for the first time for very efficient Knoevenagel condensation. Molecular complexes are thermally stable, easily recyclable, and have a low cost of preparation. T
Reactivity of Nitroalkyl Anions Addition to Substituted Benzylidenecyanoacetates: Electrophilicity Parameters and Free Energy Relationships
Azaiez,Dhahri,Boubaker
, p. 847 - 858 (2017)
The kinetics of the reactions of benzylidenecyanoacetates 1a–d (X = H, Me, OMe, and NMe2) with nitroalkyl anions 2a–c have been studied in aqueous solution at 20°C. The second-order rate constants are used to evaluate the electrophilicity param
Polycarbosilane-supported titanium(IV) catalyst for Knoevenagel condensation reaction
Mangala, Kunniyur,Sreekumar, Krishnapillai
, p. 73 - 78 (2013)
Polycarbosilane (PCS) was synthesized by the polycondensation of trichloromethylsilane and trimethoxyvinylsilane in the presence of sodium metal. PCS has a highly crosslinked structure, high ceramic yield and high surface area. Titanium metal ion was attached to the polycarbosilane and its catalytic activity was investigated. The Knoevenagel condensation reaction catalysed by titanium-incorporated polycarbosilane is reported. The titanium-incorporated PCS catalysed the reaction well and with a diverse set of substrates the reaction proceeded with good yield. PCS-supported transition metal catalysts have been prepared for the first time and used successfully in the Knoevenagel condensation reaction. Copyright
Leucoemeraldine-Base-Catalyzed Knoevenagel Condensation
Zhang, Ai-Qin,Zhang, Ning,Hong, Sanguo,Zhang, Ming
, p. 3024 - 3030 (2009)
A facile method for Knoevenagel condensation has been developed by using Leucoemeraldine base as catalyst to give substituted alkenes in excellent yields. The recycling of the solid catalyst was investigated.
Knoevenagel condensation of aldehydes with active methylene compounds catalyzed by MgC2O4/SiO2 under microwave irradiation and solvent-free conditions
Yuan, Shizhen,Li, Zhen,Xu, Ling
, p. 393 - 402 (2012)
MgC2O4/SiO2 catalyzes the efficient Knoevenagel condensation of aldehydes with active methylene compounds in solvent-free conditions under microwave irradiation to give alkenes derivatives in excellent yields. MgC2/s
Water mediated procedure for preparation of stereoselective oximes as inhibitors of MRCK kinase
Luqman, Suaib,Misra, Krishna,Pandey, Jyoti,Shrivash, Manoj Kumar,Shukla, Akhilesh Kumar,Singh, Shilipi
, (2020/07/08)
Stereoselective aldoximes, preferably Z form have been obtained from α-cyano substituted carbonyl conjugated alkenes. This reaction occurs through Michael addition type reaction followed by retro-Knoevenagel reaction without transition-metal catalysis via C–C bond cleavage. These oximes are evaluated against cancer cell lines employing mechanistic study. Two oximes showed significant cytotoxic activity, which through in silico studies were found to inhibit MRCK Kinase, responsible for metastatic spread of cancer mortality.
Molybdenum oxide nanoparticles as recyclable heterogeneous catalyst for synthesis of arylidene ethyl cyanoacetates
Pourshojaei, Yaghoub,Eskandari, Khalil,Elhami, Elaheh,Asadipour, Ali
, p. 5965 - 5973 (2019/06/14)
This work reports an adapted route to the highly efficient synthesis of arylidene ethyl cyanoacetate derivatives in the presence of catalytic amounts of molybdenum oxide nanoparticles (MoO3 NPs) under green conditions at ambient temperature. From the reaction, a wide range of novel arylidene ethyl cyanoacetates was successfully synthesized with high yields from the Knoevenagel condensation reaction between various aryl aldehydes and ethyl cyanoacetate in the presence of MoO3 nanoparticles. The capability of catalyst to separate from the reaction mixture and then reuse is another advantage of this reaction. Furthermore, obtained products belong to analogous of organic compounds that have shown biological activity, and can be used pharmaceutics.
Prolinamide functionalized polyacrylonitrile fiber with tunable linker length and surface microenvironment as efficient catalyst for Knoevenagel condensation and related multicomponent tandem reactions
Zhu, Hai,Xu, Gang,Du, Huimin,Zhang, Chenlu,Ma, Ning,Zhang, Wenqin
, p. 217 - 229 (2019/05/16)
A series of new prolinamide polyacrylonitrile fiber catalysts with tunable length of alkyl linker and different linker group were prepared by covalent bonding for the first time and well characterized by mechanical strength, FT-IR, XRD, EA, TGA, SEM and water contact angel. The catalytic activities of these fiber catalysts were evaluated in Knoevenagel condensation and one-pot Knoevenagel-Michael multicomponent tandem reactions to synthesize α, β-unsaturated nitrile and 2-amino-4H-chromene derivatives in water. The result show that the suitable linker length attaching amines to fiber matrix as well as the constructed hydrophobic microenvironment by linker group within the surface layers of fiber materials effectively promotes the reactions. In addition, the good swollen capacity of fiber in solvent ensure that the reaction proceed well. Fiber catalyst PANPA?2F modified by prolinamide with a C2 alkyl chain exhibited the best catalytic performance and can be easily recovered and reused for at least ten consecutive cycles without significant loss of catalytic activity and active sites leaching.
