144-14-9

Basic information

• Product Name: Anileridine
• Synonyms: anileridine base;1-(p-AMinophenethyl)-4-phenylisonipecotic Acid Ethyl Ester;1-(p-AMinophenethyl)-4-phenylpiperidine-4-carboxylic Acid Ethyl Ester;1-[2-(4-AMinophenyl)ethyl]-4-phenyl-4-piperidinecarboxylic Acid Ethyl Ester;Adopol;Alidine;Apidol;Ethyl 1-(4
• CAS NO: 144-14-9
• Molecular Formula: C₂₂H₂₈N₂O₂
• Molecular Weight: 352.475
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals
• Mol File: 144-14-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: 83°C
• Boiling Point: 486.07°C (rough estimate)
• Flash Point: 251.1°C
• Appearance: /
• Density: 1.1096 (rough estimate)
• Vapor Pressure: 8.31E-10mmHg at 25°C
• Refractive Index: 1.6500 (estimate)
• PKA: 8.41±0.10(Predicted)
• CAS DataBase Reference: Anileridine(CAS DataBase Reference)
• NIST Chemistry Reference: Anileridine(144-14-9)
• EPA Substance Registry System: Anileridine(144-14-9)

Safety Data

• RIDADR: 1544
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 144-14-9(Hazardous Substances Data)

Usage

Description

Anileridine is a synthetic analgesic drug belonging to the 4-phenylpiperidine class. It is an analog of Meperidine (M223900) and is characterized by its increased analgesic activity. Anileridine is a piperidinecarboxylate ester that is the ethyl ester of isonipecotic acid, with a phenyl group substituted at the hydrogen alpha-to the carboxyl group and a 2-(4-aminophenyl)ethyl group substituted at the hydrogen attached to the nitrogen.

Uses

Used in Pharmaceutical Industry:
Anileridine is used as an analgesic agent for its potent pain-relieving properties. It is particularly effective in managing moderate to severe pain due to its increased analgesic activity compared to other drugs in its class.
Used in Pain Management:
Anileridine is used as a pain management medication for various conditions that cause acute or chronic pain. Its high efficacy in alleviating pain makes it a valuable option for patients seeking relief from discomfort and distress.
Used in Research and Development:
Anileridine is also utilized in the research and development of new pharmaceuticals, particularly in the field of analgesics. Its unique chemical structure and properties provide valuable insights for the development of more effective and safer pain-relieving drugs.

Therapeutic Function

Narcotic analgesic

Safety Profile

Poison by ingestion,subcutaneous, intravenous, and intraperitoneal routes.When heated to decomposition it emits toxic fumes ofNOx.

InChI:InChI=1/C22H28N2O2/c1-2-26-21(25)22(19-6-4-3-5-7-19)13-16-24(17-14-22)15-12-18-8-10-20(23)11-9-18/h3-11H,2,12-17,23H2,1H3

Upstream product

• 64-17-5 ethanol 
• 5339-26-4 (4-nitrophenyl)ethyl bromide 
• 52273-60-6 4-(2-chloro-ethyl)-aniline; hydrochloride 
• 114160-43-9 1-(4-nitro-phenethyl)-4-phenyl-piperidine-4-carboxylic acid ethyl ester 
• 24465-45-0 ethyl 4-phenyl-4-piperidinecarboxylate hydrochloride 

Downstream Products

• 57604-00-9 1-(4-acetylamino-phenethyl)-4-phenyl-piperidine-4-carboxylic acid ethyl ester 

Relevant articles and documents

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