144025-14-9 Usage
Description
DEMETHYLCITALOPRAM, also known as N-Desmethylcitalopram hydrochloride, is an active metabolite of the selective serotonin reuptake inhibitor (SSRI) antidepressant drug Citalopram. It is an off-white solid that plays a significant role in the treatment of major depression and mood disorders. DEMETHYLCITALOPRAM functions as an inhibitor of serotonin (5-HT) uptake, thereby increasing the availability of serotonin in the synaptic cleft and improving mood regulation.
Uses
Used in Pharmaceutical Industry:
DEMETHYLCITALOPRAM is used as an antidepressant for the treatment of major depression associated with mood disorders. It acts by inhibiting the reuptake of serotonin, a neurotransmitter responsible for regulating mood, appetite, and sleep, among other functions. This increased availability of serotonin in the synaptic cleft helps alleviate the symptoms of depression and improve the overall well-being of the patient.
DEMETHYLCITALOPRAM is used as a metabolite in the development and understanding of the pharmacological effects of Citalopram. As an active metabolite, it contributes to the overall efficacy of the parent drug, Citalopram, in treating depression and mood disorders. This knowledge aids researchers and pharmaceutical companies in the development of more effective and targeted antidepressant medications.
In addition to its use as an antidepressant, DEMETHYLCITALOPRAM may also be utilized in research studies to better understand the mechanisms of action and potential side effects of SSRI antidepressants. This information can be valuable in the development of new treatments and therapies for depression and other mood disorders.
Overall, DEMETHYLCITALOPRAM plays a crucial role in the pharmaceutical industry as a component of antidepressant medications and as a subject of research for the advancement of mental health treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 144025-14-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,0,2 and 5 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 144025-14:
(8*1)+(7*4)+(6*4)+(5*0)+(4*2)+(3*5)+(2*1)+(1*4)=89
89 % 10 = 9
So 144025-14-9 is a valid CAS Registry Number.
144025-14-9Relevant articles and documents
Preparation method of escitalopram oxalate demethylation impurity
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Paragraph 0017, (2017/08/29)
The invention provides a brand-new preparation method of 1-(4- fluorophenyl)-1-(3-(fluorophenyl)propyl)-1,3-dihydroisobenzofiaran-5-formonitrile as an escitalopram oxalate process impurity. The brand-new preparation method provides a reference for qualitatively and quantitatively analyzing impurity conditions in a finished product of escitalopram oxalate, has an important effect on quality control of the escitalopram oxalate, and can promote safe medication of depressed patients.
Novel and high affinity fluorescent ligands for the serotonin transporter based on (S)-citalopram
Kumar, Vivek,Rahbek-Clemmensen, Troels,Billesb?lle, Christian B.,Jorgensen, Trine Nygaard,Gether, Ulrik,Newman, Amy Hauck
, p. 696 - 699 (2014/07/07)
Novel rhodamine-labeled ligands, based on (S)-citalopram, were synthesized and evaluated for uptake inhibition at the human serotonin, dopamine, and norepinephrine transporters (hSERT, hDAT, and hNET, respectively) and for binding at SERT, in transiently
Enantioenriched synthesis of Escitalopram using lithiation-borylation methodology
Partridge, Benjamin M.,Thomas, Stephen P.,Aggarwal, Varinder K.
supporting information; experimental part, p. 10082 - 10088 (2012/02/05)
The asymmetric synthesis of Escitalopram has been completed using a lithiation-borylation reaction as the key step. Suitably functionalized enantioenriched carbamate (er 98:2) and boronic ester coupling partners were prepared and following deprotonation with s-BuLi and borylation, the tertiary alcohol was obtained in 42% yield and 93:7 er. The lithiation-borylation reaction was found to tolerate nitrile, benzylic alcohol and N-Boc functionalities. The tertiary alcohol was converted to Escitalopram in three further steps.
