144092-64-8

Basic information

• Product Name: HA 23
• Synonyms: HA 23
• CAS NO: 144092-64-8
• Molecular Formula: C₁₃H₁₂N₂O₂S
• Molecular Weight: 260.31158
• Mol File: 144092-64-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 473°Cat760mmHg
• Flash Point: 239.8°C
• Appearance: /
• Density: 1.38g/cm³
• Vapor Pressure: 4.09E-09mmHg at 25°C
• Refractive Index: 1.683
• CAS DataBase Reference: HA 23(CAS DataBase Reference)
• NIST Chemistry Reference: HA 23(144092-64-8)
• EPA Substance Registry System: HA 23(144092-64-8)

Safety Data

• Hazardous Substances Data: 144092-64-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H12N2O2S/c1-8-6-11(16)17-13-12(8)9(2)15(14-13)7-10-4-3-5-18-10/h3-6H,7H2,1-2H3

Upstream product

• 45438-73-1 2-thenyl bromide 
• 5203-98-5 3,4-dimethyl-1H-pyrano[2,3-c]pyrazol-6-one 

Relevant articles and documents

Synthesis and antiplatelet activities of N-arylmethyl-3,4-dimethylpyrano[2,3-c]pyrazol-6-one derivatives

A series of new 1- and 2-arylmethyl-3,4-dimethylpyrano[2,3-c]pyrazol-6-one derivatives were synthesized and examined for their antiplatelet activities. Some of these compounds showed significant inhibitory activities. Among them, 1-phenylmethyl-3,4-dimethylpyrano[2,3-c]pyrazol-6(1H)-one (4a), 2-(2'-methoxyphenyl)methyl-3,4-dimethylpyrano[2,3-c]pyrazol-6(2H)-one (3e) and 2-(3'-methoxyphenyl)methyl-3,4-dimethylpyrano[2,3-c]pyrazol-6-(2H)-one (3f) were the most effective. These inhibitors acted in a concentration-dependent manner. The antiplatelet effect of compound 3f is due to the inhibition of thromboxane A2 formation and the blockade of thromboxane A2/prostaglandin endoperoxide receptor in washed rabbit platelets.