144127-48-0Relevant articles and documents
Dynemicin analogs: syntheses, methods of preparation and use
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, (2008/06/13)
A fused ring system compound is disclosed that contains an epoxide group on one side of the fused rings and an enediyne macrocyclic ring on the other side of the fused rings. The compounds have DNA-cleaving, antimicrobial and tumor growth-inhibiting properties. Chimeric compounds having the fused ring system compound as an aglycone bonded to (i) a sugar moiety as the oligosaccharide portion or (ii) a monoclonal antibody or antibody combining site portion thereof that immunoreacts with target tumor cells are also disclosed. Compositions containing a compound or a chimer are disclosed, as are methods of preparing a compound.
Molecular design and chemical synthesis of potent enediynes. 1. Dynemicin model systems equipped with N-tethered triggering devices
Nicolaou,Maligres,Suzuki,Wendeborn,Dai,Chadha
, p. 8890 - 8907 (2007/10/02)
In this article the molecular design and chemical synthesis of a series of enediynes (12-19, Chart I) related to the dynemicin A structure and carrying N-tethered triggering devices are described. The design envisioned the [(arylsulfonyl)ethoxy]carbonyl g
