144163-81-5

Basic information

• Product Name: METHYL-(2-METHYL-THIAZOL-4-YLMETHYL)-AMINE
• Synonyms: CHEMBRDG-BB 4101062;METHYL-(2-METHYL-THIAZOL-4-YLMETHYL)-AMINE;N,2-Dimethyl-(1,3-thiazol-4-yl)methylamine;2-Methyl-4-[methyl(aminomethyl)]-1,3-thiazole;2-Methyl-4-[methyl(aminomethyl)]-1,3-thiazole 97%;N-Methyl-N-[(2-methyl-1,3-thiazol-4-yl)methyl]amine;N-methyl(2-methylthiazol-4-yl)methanaminedihydrochloride;Methyl-(2-methyl thiazole-4-yl methyl)amine
• CAS NO: 144163-81-5
• Molecular Formula: C₆H₁₀N₂S
• Molecular Weight: 142.22
• Product Categories: Building Blocks;Thiazole
• Mol File: 144163-81-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 207.1 °C at 760 mmHg
• Flash Point: 79.1 °C
• Appearance: /
• Density: 1.093 g/cm³
• Vapor Pressure: 0.229mmHg at 25°C
• Refractive Index: 1.538
• PKA: 8.10±0.10(Predicted)
• CAS DataBase Reference: METHYL-(2-METHYL-THIAZOL-4-YLMETHYL)-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL-(2-METHYL-THIAZOL-4-YLMETHYL)-AMINE(144163-81-5)
• EPA Substance Registry System: METHYL-(2-METHYL-THIAZOL-4-YLMETHYL)-AMINE(144163-81-5)

Safety Data

• Hazard Codes: C
• Hazardous Substances Data: 144163-81-5(Hazardous Substances Data)

Usage

General Description

Methyl-(2-methyl-thiazol-4-ylmethyl)-amine is a chemical compound with the molecular formula C8H12N2S. It belongs to the class of organic compounds known as thiazoles, which are heterocyclic compounds containing a five-membered ring consisting of three carbon atoms, one nitrogen atom, and one sulfur atom. METHYL-(2-METHYL-THIAZOL-4-YLMETHYL)-AMINE is a derivative of thiazole with a methyl substituent at the 2-position and an amino group at the 4-position, attached to a methyl group. It is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds due to its versatile reactivity and functional group compatibility. Methyl-(2-methyl-thiazol-4-ylmethyl)-amine is also used as a precursor in the production of various specialty chemicals and has potential applications in research and development in the pharmaceutical and chemical industries.

InChI:InChI=1/C6H10N2S/c1-5-8-6(3-7-2)4-9-5/h4,7H,3H2,1-2H3

Upstream product

• 77470-53-2 4-chloromethyl-2-methylthiazole hydrochloride 
• 74-89-5 methylamine 
• 39238-07-8 4-(chloromethyl)-2-methyl-1,3-thiazole 
• 62-55-5 thioacetamide 
• 534-07-6 1,3-Dichloroacetone 

Relevant articles and documents

Structure-activity relationships of diamine inhibitors of cytochrome P450 (CYP) 3A as novel pharmacoenhancers. Part II: P2/P3 region and discovery of cobicistat (GS-9350)

The HIV protease inhibitor (PI) ritonavir (RTV) has been widely used as a pharmacoenhancer for other PIs, which are substrates of cytochrome P450 3A (CYP3A). However the potent anti-HIV activity of ritonavir may limit its use as a pharmacoenhancer with other classes of anti-HIV agents. Ritonavir is also associated with limitations such as poor physicochemical properties. To address these issues a series of compounds with replacements at the P2 and/or P3 region was designed and evaluated as novel CYP3A inhibitors. Through these efforts, a potent and selective inhibitor of CYP3A, GS-9350 (cobicistat) with improved physiochemical properties was discovered.

HIV protease inhibiting compounds

A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.

HIV protease inhibiting compounds

A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.