144163-88-2Relevant articles and documents
Directed reductive amination of β-hydroxy-ketones: Convergent assembly of the ritonavir/lopinavir core
Menche, Dirk,Arikan, Fatih,Li, Jun,Rudolph, Sven
, p. 267 - 270 (2007/10/03)
(Chemical Equation Presented) An efficient procedure for the directed reductive amination of β-hydroxy-ketones (3) for the stereoselective preparation of 1,3-syn-amino alcohols (6) is reported. The operationally simple protocol uses Ti(iOPr)su
Small hydroxyethylene-based peptidomimetics inhibiting both HIV-1 and C. albicans aspartic proteases
Tossi, Alessandro,Benedetti, Fabio,Norbedo, Stefano,Skrbec, Damiano,Berti, Federico,Romeo, Domenico
, p. 4719 - 4727 (2007/10/03)
We have extended a highly flexible method for rapidly assembling aspartic protease inhibitors to produce symmetric and asymmetric monohydroxyethylene peptidomimetics. This method is based on the prior synthesis of the central non-cleavable peptide-bond is
Epoxyalcohol route to hydroxyethylene dipeptide isosteres: A new synthesis of the diaminoalcohol core of HIV-protease inhibitor ABT-538 (Ritonavir)
Benedetti,Norbedo
, p. 203 - 204 (2007/10/03)
A stereoselective synthesis of the diaminoalcohol core of Ritonavir illustrates a novel approach to hydroxyethylene dipeptide isosteres, based on the regioselective reduction of amino acid-derived epoxyalcohols.