144175-29-1

Basic information

• Product Name: Benzamide, 4-chloro-N-(chloromethyl)-N-methyl-
• CAS NO: 144175-29-1
• Molecular Formula: C9H9Cl2NO
• Molecular Weight: 218.083
• Mol File: 144175-29-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzamide, 4-chloro-N-(chloromethyl)-N-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 4-chloro-N-(chloromethyl)-N-methyl-(144175-29-1)
• EPA Substance Registry System: Benzamide, 4-chloro-N-(chloromethyl)-N-methyl-(144175-29-1)

Safety Data

• Hazardous Substances Data: 144175-29-1(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 6873-44-5 p-chloro-N-methylbenzamide 

Downstream Products

• 144175-22-4 N-(diphenyloxophosphinyl)methyl-N-methyl-4-chlorobenzamide 
• 158877-61-3 (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid [(4-chloro-benzoyl)-methyl-amino]-methyl ester 

Relevant articles and documents

A New Direct Synthesis of Tertiary N-Acyloxymethylamide Prodrugs of Carboxylic Acid Drugs

N-Alkyl-N-chloromethylamides 2, prepared from secondary amides, paraformaldehyde and chlorotrimethylsilane, react readily with carboxylate anions to generate the corresponding tertiary N-acyloxymethylamides 3 in good yield; the latter give rise to the parent carboxylic acids in aqueous media at pH 7.4 and 37 deg C with half-lives between ca. 1 min and 42 h.