14419-11-5 Usage
Description
Ornidazole IsoMer (IMpurity) is an isomeric impurity of Ornidazole, a pharmaceutical compound with anti-infective properties. It is derived from the parent compound Ornidazole, which is commonly used for treating various infections caused by anaerobic bacteria and protozoa. The isomeric nature of this impurity suggests that it shares similar chemical properties with the parent compound, while having a distinct structural arrangement.
Uses
Used in Pharmaceutical Industry:
Ornidazole IsoMer (IMpurity) is used as an active pharmaceutical ingredient (API) for its anti-infective properties. It maintains the ability to combat infections caused by anaerobic bacteria and protozoa, making it a valuable addition to the treatment options for various medical conditions.
Used in Research and Development:
Ornidazole IsoMer (IMpurity) can be utilized in research and development for studying the effects of isomeric impurities on the efficacy, safety, and pharmacokinetics of the parent compound, Ornidazole. This can help in understanding the potential benefits and risks associated with the use of isomeric impurities in pharmaceutical formulations.
Used in Quality Control and Regulatory Compliance:
Ornidazole IsoMer (IMpurity) is also used in the quality control and regulatory compliance processes of pharmaceutical manufacturing. It serves as a reference material for testing and validating the purity, potency, and stability of Ornidazole-based drug products, ensuring that they meet the required standards for safety and efficacy.
Check Digit Verification of cas no
The CAS Registry Mumber 14419-11-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,4,1 and 9 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 14419-11:
(7*1)+(6*4)+(5*4)+(4*1)+(3*9)+(2*1)+(1*1)=85
85 % 10 = 5
So 14419-11-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H10ClN3O3/c1-5-9-7(11(13)14)4-10(5)3-6(12)2-8/h4,6,12H,2-3H2,1H3
14419-11-5Relevant articles and documents
Lipase-catalyzed resolution of both enantiomers of Ornidazole and some analogues
Skupin, Rolf,Cooper, Trevor G.,Froehlich, Roland,Prigge, Joerg,Haufe, Guenter
, p. 2453 - 2464 (1997)
The resolution of the enantiomers of the chemotherapeutic Ornidazole (Tiberal) 1a was achieved by acetylation of the racemic compound with vinylacetate in the presence of lipase Amano PS (from Pseudomonas cepacia). The halogen analogues 4a-6a and the corresponding 4-nitro-derivatives 1b and 4b-6b were also synthesized and the enantiomers were separated by kinetic enzymatic resolution. The absolute configuration of two compounds was determined by X-ray crystallography.
2-methyl-4-nitroimidazole derivatives and preparation method thereof, and application of pharmaceutical compositions
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Paragraph 0023, (2017/10/22)
The invention provides 2-methyl-4-nitroimidazole derivatives and a preparation method of the 2-methyl-4-nitroimidazole derivatives. Besides, pharmaceutical compositions containing the 2-methyl-4-nitroimidazole derivatives are applicable to treatment of many infectious diseases caused by Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus, Clostridium, Eubacterium, Peptococcus and Peptostreptococcus, Helicobacter pylori, Bacteroides melaninogenicus, Fusobacterium, Capnocytophaga, Bacteroides gingivalis and other sensitive anaerobic bacteria.
